抗Homer3抗体阳性自身免疫性小脑共济失调1例并文献复习  

Autoimmune cerebellar ataxia with positive anti-Homer3 antibody: a case report and literature review

作　　者：贾俊丽 徐广润[1] 孔文程 Jia Junli;Xu Guangrun;Kong Wencheng(Department of Neurology,Qilu Hospital,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学齐鲁医院神经内科,济南250012

出　　处：《中华神经科杂志》2022年第12期1407-1412,共6页Chinese Journal of Neurology

摘　　要：自身免疫性小脑性共济失调(ACA)是一种自身免疫机制介导的小脑综合征,抗Homer蛋白3(Homer3)抗体阳性的ACA十分罕见。文中报道1例山东大学齐鲁医院收治的患者,55岁男性,主因“头晕、行走不稳22 d”就诊,血清及脑脊液检测结果示抗Homer3抗体阳性,给予静脉注射免疫球蛋白联合激素治疗,症状好转。通过对该病例资料及相关文献报道的复习,分析抗Homer3抗体阳性ACA的发病机制、临床表现、辅助检查、治疗及预后,加深临床医生对其的认识,提高诊治水平。Autoimmune cerebellar ataxia(ACA)is a cerebellar syndrome mediated by autoimmune mechanisms,and ACA with positive anti-Homer3 antibody is very rare.This article reports a 55-year-old male patient admitted to Qilu Hospital,Shandong University,due to dizziness and walking instability for 22 days.The serum and cerebrospinal fluid showed positive results for anti-Homer3 antibody,and the symptoms improved after intravenous immunoglobulin combined with hormone therapy.Based on the review of the case data and relevant literature reports,the pathogenesis,clinical manifestations,auxiliary examination,treatment and prognosis of ACA with positive anti-Homer3 antibody are analyzed,so as to deepen the understanding of clinicians and improve the diagnosis and treatment level.

关 键 词：小脑共济失调 自身免疫 Homer3蛋白 代谢性谷氨酸受体1型 Shank蛋白 

分 类 号：R744.7[医药卫生—神经病学与精神病学]