胶质淋巴系统在帕金森病中的研究进展  

Glymphatic system in Parkinson′s disease

作　　者：王韬 卢秀芳[2] 王荔[2] Wang Tao;Lu Xiufang;Wang Li(Department of Neurology,the Second Hospital of Shanxi Medical University,the Second Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China;Department of Neurology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院神经内科山西医科大学第二临床医学院,太原030001 [2]山西医科大学第二医院神经内科,太原030001

出　　处：《中华神经科杂志》2022年第12期1434-1441,共8页Chinese Journal of Neurology

摘　　要：帕金森病是脑内异常蛋白沉积为主要病理改变的中枢神经系统退行性疾病,目前认为与异常沉积蛋白清除障碍有关,至今相关机制仍不明确。胶质淋巴系统是脑内代谢废物及异常蛋白沉积清除系统,近年来研究结果表明,帕金森病中水通道蛋白4、血管周围间隙及硬脑膜淋巴管改变与脑脊液中相关病理蛋白的水平密切相关,最终导致帕金森病的发生与发展。文中对近年来帕金森病中胶质淋巴系统结构及生物标志物研究进行综述。Parkinson′s disease is a degenerative disease of the central nervous system with abnormal protein deposition in the brain as the main pathological changes.The onset of Parkinson′s disease is related to abnormal deposition protein removal disorders,and the relevant mechanisms are still unclear.The glymphatic system is a metabolic waste and abnormal protein deposition removal system in the brain.In recent years,studies have shown that the changes of aquaporin 4,perivascular space and dural lymphatic vessels in Parkinson′s disease are closely related to the level of relevant pathological proteins in cerebrospinal fluid,leading to the occurrence and development of Parkinson′s disease.The researches on structure and biomarkers of the glymphatic system in Parkinson′s disease in recent years are reviewed in this article.

关 键 词：帕金森病 水通道蛋白质4 Α突触核蛋白 淀粉样蛋白 TAU蛋白质类 胶质淋巴系统 血管周围间隙 

分 类 号：R742.5[医药卫生—神经病学与精神病学]