Camganoids A and B,two new sesquiterpenes with different carbon skeletons isolated from fruits of Cinnamomum migao  

作　　者：Yongzhen Xiao Ishaq Muhammad Xianpeng Ma Huajun Yu Shikai Yan Xue Xiao Huizi Jin 

机构地区：[1]Department of Natural Product Chemistry,School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China [2]Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China [3]Guizhou Jingcheng Pharmaceutical Co.,Ltd.,Guiyang 550200,China [4]Institute of Chinese Medicinal Sciences,Guangdong Pharmaceutical University,Guangzhou 510006,China

出　　处：《Chinese Herbal Medicines》2022年第4期638-642,共5页中草药（英文版）

基　　金：supported by NSFC(81973191);Natural Science Foundation of Shanghai(19ZR1428100);Project supported by the Department of Science and Technology of Guizhou(Grant No.[2018]2831);the Horizontal Research Project of Shanghai Jiao Tong University(SA1700111,SA1700118)。

摘　　要：Objective:To isolate and identify the undescribed compounds from the fruits of Cinnamomum migao and evaluate its nitric oxide inhibition potential.Methods:The chromatographic techniques of silica gel,Sephadex,and HPLC were used for isolation and purification of the compounds,while HR-ESI-MS,1D NMR,2D NMR,ECD,and X-ray diffraction techniques were used to characterize and confirm the isolated compounds.Moreover,the antiinflammatory activity of the isolated compounds was carried out to check inhibitory potential against the production of nitric oxide with RAW264.7 cells stimulated by LPS.Results:Camganoid A(1),a novel sesquiterpene possessing an unprecedented skeleton,and camganoid B(2),containing a unique eight-membered sesquiterpene moiety with a new carbon skeleton,were isolated and identified from the fruits of C.migao.The absolute configurations of 1 and 2 were confirmed by single crystal X-ray diffraction and electronic circular dichroism(ECD)calculations.Among these compounds,compound 1 exhibited potent inhibitory activity against the production of nitric oxide with IC50value of 4.59μmol/L in RAW264.7 cells stimulated by LPS.Conclusion:The isolation of two new skeletons from the fruits part of C.migao possessed unique skeletons which have not been reported before.

关 键 词：Cinnamomum migao H.W.Li nitric oxide inhibition SESQUITERPENE 

分 类 号：R284.1[医药卫生—中药学]