SESQUITERPENE

作品数：136被引量：328H指数：8
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相关领域：理学医药卫生更多>>
相关作者：高振黄和刘欣纪晓俊马小琛更多>>
相关机构：江苏省工业生物技术创新中心南京工业大学中国科学院中国科学院植物研究所更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家科技支撑计划天津市自然科学基金更多>>
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Penijanacoranes A-F,Acorane-Type Sesquiterpenes from a Deep Sea-Derived Fungus Penicillium janthinellum SH0301
《Chinese Journal of Chemistry》2025年第3期268-274,共7页Lu-Jia Yang Ling Lv Zhuang Han Yu-Cheng Gu Xin Li Chang-Lun Shao Zhi-Qing Liu Chang-Yun Wang 
supported by grants from the Major Project of Qingdao Marine Science and Technology Center(No.2022QNLM030003-1);the Fundamental Research Funds for the Central Universities of China(No.202462006);the Key Program of National Natural Science Foundation of China(No.41830535);the Syngenta PhD Scholarship to L.-J.Y.
Six new acorane-type sesquiterpenes,named penijanacoranes A—F(1—6),as well as one known eudesmane sesquiterpenoid 1α,6β,11-eudesm-triol(7)have been isolated from a deep-sea-derived fungus Penicillium janthinellum ...
关键词：Natural products Acorane-type sesquiterpene Structure elucidation Deep-sea-derived fungus Penicillium janthinellum Biological activity Anti-inflammatory activity 
Holotrichones A and B,potent anti-leukemic lindenane-type sesquiterpene trimers with unprecedented complex carbon skeletons from a rare Chloranthus species
《Chinese Chemical Letters》2024年第12期470-474,共5页Xue-Jiao Wang Jun-Li Xin Hong Xiang Ze-Yu Zhao Yu-Hang He Haibo Wang Guangyao Mei Yi-Cheng Mao Juan Xiong Jin-Feng Hu 
supported by grants from the National Natural Science Foundation of China(Nos.21772025,21937002)。
Two lindenane-type sesquiterpene(LDS)trimers with unprecedented carbon skeletons,holotrichones A(1)and B(2),were obtained from the whole plant of Chloranthus holostegius var.trichoneurus by a ultra performance liquid ...
关键词：Chloranthus holostegius var.trichoneurus Holotrichones Lindenane-type sesquiterpene trimers Acute myeloid leukemia Cell apoptosis 
Unprecedented sesquiterpene-polycyclic polyprenylated acylphloroglucinol adduct against acute myeloid leukemia via inhibiting mitochondrial complex Ⅴ
《Chinese Chemical Letters》2024年第10期305-308,共4页Zhengyi Shi Jie Yin Yang Xiao Zhangrong Hou Fei Song Jianping Wang Qingyi Tong Changxing Qi Yonghui Zhang 
supported financially by the National Natural Science Foundation for Distinguished Young Scholars(No.81725021);the National Natural Science Foundation of China(Nos.82003633 and 82104043);the National Natural Science Foundation of Hubei Province(No.2023AFB791)。
Monosescinol A(1),the first example of sesquiterpene–polycyclic polyprenylated acylphloroglucinol(PPAP)adduct,which represented a new subclass of PPAP-type natural products,along with two new congeners with normal sp...
关键词：PPAP adduct Single-crystal X-ray diffraction Keto-enol tautomerism Plausiblebiosynthetic pathway Cytotoxic activity 
Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis
《Chinese Journal of Natural Medicines》2024年第7期643-653,共11页DANG Wen GUO Tingting ZHOU Di MENG Qingqi FANG Mingxia CHEN Gang LIN Bin HOU Yue LI Ning 
supported by the National Natural Science Foundation of China(No.U1903122);the Scientific Research Fund of Liaoning Province Education Department(No.LJKZ0945);the Natural Science Foundation of Liaoning Province(No.2022-MS-242).
The resin of Ferula sinkiangensis has been traditionally utilized for treating gastrointestinal disorders,inflammation,tumors,various cancers,and alopecia areata.The primary bioactive constituents,sesquiterpene coumar...
关键词：Ferula sinkiangensis Sesquiterpene coumarins Structure elucidation Anti-neuroinflammatory activity 
Divergent total synthesis of marine meroterpenoids(+)-dysidavarones A–C
《Chinese Chemical Letters》2024年第3期234-238,共5页Qunlong Zhang Yang Kuang Le Chang Jingyi Kang Bingjian Wang Chuanke Chong Zhaoyong Lu 
financially supported by the National Natural Science Foundation of China(Nos.22171146,21971121,and 22188101 to ZL);the China Postdoctoral Science Foundation(No.2021M701775 to CC)。
Here,we report a concise and divergent enantioselective total synthesis of marine sesquiterpene quinone meroterpenoids(+)-dysidavarones A–C(1–3)using predysidavarone 6 as a key common intermediate.The highly straine...
关键词：Total synthesis Natural product Dysidavarones A–C Sesquiterpene quinone Meroterpenoid 
Profiling proteomic responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae被引量：1
《Engineering Microbiology》2023年第3期1-13,共13页Zeyu Lu Qianyi Shen Lian Liu Gert Talbo Robert Speight Matt Trau Geoff Dumsday Christopher B.Howard Claudia E.Vickers Bingyin Peng 
supported by Australian Research Council centre of Excellence in Synthetic Biology(CE200100029);supported by BioPlatforms Australia through the Commonwealth Government’s National Collaborative Research Infrastructure Strategy(NCRIS).
Hexokinase II(Hxk2)is a master protein in glucose-mediated transcriptional repression signaling pathway.De-grading Hxk2 through an auxin-inducible protein degradation previously doubled sesquiterpene(nerolidol)pro-duc...
关键词：PROTEOMICS Glucose repression Metabolic engineering Crabtree effect SESQUITERPENE Synthetic biology Genetic regulation 
Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity被引量：1
《Acta Pharmaceutica Sinica B》2023年第9期3930-3944,共15页Xin Tang Chuanxi Wang Lei Wang Feifei Ren Runqiao Kuang Zhenhua Li Xue Han Yiming Chen Guodong Chen Xiuqing Wu Jie Liu Hengwen Yang Xingzhong Liu Chen Wang Hao Gao Zhinan Yin 
supported by the National Key Research and Development Program of China(2018YFA0903200,2018YFA0903201,and 2020YFA0803502);the National Natural Science Foundation of China(81925037,U22A20371,31830021,32030036,and 82270055);the 111 Project(B16021,China);National High-level Personnel of Special Support Program(2017RA2259,China);Guangdong International Science and Technology Cooperation Base(2021A0505020015,China);Innovative and Research Teams Project of Guangdong Higher Education Institution(2021KCXTD001,China);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036,China);Guangdong Natural Science Funds for Distinguished Young Scholar(2021B1515020065,China)。
Interleukin(IL)-17A,a pro-inflammatory cytokine,is a fundamental function in the onset and advancement of multiple immune diseases.To uncover the primary compounds with IL-17A inhibitory activity,a large-scale screeni...
关键词：Aureane-type sesquiterpene tetraketides IL-17A Experimental autoimmune encephalomyelitis Pulmonary hypertension 
Isolation and identification of endophytic fungi involved in the promotion of sesquiterpene accumulation in Syringa pinnatifolia
《Science of Traditional Chinese Medicine》2023年第2期129-136,共8页Jiaqi Gao Shiou Yih Lee Badalahu Tai Xingyun Chai Juan Liu 
This research was funded by the CACMS Innovation Fund(CI2021A04101);the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ13-YQ-093-C1).
Background:The stemof Syringa pinnatifolia is used as traditionalMongolian medicine for the treatment of cardiopulmonary diseases,in which sesquiterpenes are regarded as the primary medicinal compounds.However,only S....
关键词：Syringa pinnatifolia SESQUITERPENE Fungal endophytes METABOLOME 
Cytotoxic sesquiterpene aryl esters from Armillaria gallica 012m被引量：1
《Chinese Herbal Medicines》2023年第2期343-346,共4页Yanping Li Shuizhu Lou Run Yang Ling Zhang Qiuping Zou Shanzhai Shang Lu Gao Weiguang Wang 
This project was in part supported financially by National Natural Science Foundation of China(Nos.31960095 and 82160670);National Natural Science Foundation of Yunnan Province(Nos.202101AS070022 and 202201AT070228);Yunnan Ten thousand Talents Program to Weiguang Wang and Yanping Li.
Objective:To study the chemical constituents of the EtOAc extract of Armillaria gallica 012m.Methods:The chemical constituents of the EtOAc extract of A.gallica 012m were isolated and purified by various column chroma...
关键词：Armillaria gallica 012m armimelleolide C cytotoxic activity sesquiterpene aryl esters TRICHOLOMATACEAE 
Anti-inflammatory sesquiterpene polyol esters from the stem and branch of Tripterygium wilfordii被引量：1
《Chinese Journal of Natural Medicines》2023年第3期233-240,共8页HU Yalin XU Tianqi YIN Wenjing CHENG Huaiyu ZHANG Xia LIU Ying ZHANG Yubo ZHOU Guangxiong 
the Natural Science Foundation Committee of Guangdong Province(No.32220053);the National Key R&D Program of China(No.2017YFC1703800).
The stem and branch extract of Tripterygium wilfordii(Celastraceae)afforded seven new dihydroagarofuran sesquiterpene polyesters[tripterysines A‒G(1‒7)]and eight known ones(8‒15).The chemical structures of these new c...
关键词：Tripterygium wilfordii Sesquiterpene polyester Tripterysine ANTI-INFLAMMATION 
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