不同价态钒氧化物的细胞毒性评估  

Cytotoxicity Evaluation of Vanadium Oxides with Different Valences

作　　者：唐露 路学光 毛振娅 施奇武[1] 余修贤 万城渝 彭穗 刘波 黄婉霞[1] TANG Lu;LU Xueguang;MAO Zhenya;SHI Qiwu;YU Xiuxian;WAN Chengyu;PENG Sui;LIU Bo;HUANG Wanxia(College of Materials Science and Engineering,Sichuan University,Chengdu 610065,Sichuan,China;Department of Integrated Western and Chinese Medicine at West China Hospital,Sichuan University,Chengdu 610065,Sichuan,China;Chengdu Advanced Metal Materials Industrial Technology Institute Co.,Ltd.,Chengdu 610300,Sichuan,China)

机构地区：[1]四川大学材料科学与工程学院,四川成都610065 [2]四川大学华西医院中药药理研究室,四川成都610065 [3]成都先进金属材料产业技术研究院股份有限公司,四川成都610300

出　　处：《济南大学学报（自然科学版）》2023年第1期77-83,共7页Journal of University of Jinan(Science and Technology)

基　　金：国家自然科学基金项目(61771327,U20A20212,U1930123)。

摘　　要：为了对单斜晶型M相二氧化钒粉体氧化过程中可能形成的多种价态钒氧化物的细胞毒性进行评估,选取并制备价态依次增加的二氧化钒、十三氧化六钒、一水合七氧化三钒和五氧化二钒4种钒氧化物,通过细胞形态观察和细胞活性测定2种方式评估不同价态及质量浓度为1~500 mg/L的钒氧化物对小鼠成纤维细胞L929的细胞毒性。结果表明,处理24 h后的L929细胞的细胞活性在不同价态钒氧化物中由弱到强的顺序为五氧化二钒、一水合七氧化三钒、十三氧化六钒、二氧化钒,说明钒氧化物的细胞毒性随着价态的增加而增强。To evaluate cytotoxicity of vanadium oxides with different valences that may be formed during oxidation of monoclinic M-phase VO2powders, four types of vanadium oxides of VO2, V6O13, V3O7·H2O, and V2O5with increasing valences were selected and prepared. Cytotoxicity of vanadium oxides with different valences and mass concentrations of 1 mg/L to 500 mg/L to mouse fibroblasts L929 was evaluated by two means of cell morphology observation and cell viability determination. The results show that the cell viability of L929 cells treated for 24 h is in the order of V2O5, V3O7·H2O, V6O13, and VO2from weak to strong in vanadium oxide with different valences, indicating that the cytotoxicity of vanadium oxides increases with the increase of valence state.

关 键 词：钒氧化物 细胞毒性 细胞形态 细胞活力 

分 类 号：X172[环境科学与工程—环境科学]