螺旋断层全身皮肤照射治疗的研究进展  

Research progress on total skin irradiation using helical tomotherapy

作　　者：王海洋[1,2] 皮一飞 刘春波 韩滨 孔凡洋 姬腾飞 裴曦 徐榭[2] 郭跃信[1] Wang Haiyang;Pi Yifei;Liu Chunbo;Han Bin;Kong Fanyang;Ji Tengfei;Pei Xi;Xu Xie George;Guo Yuexin(Department of Radiation Oncology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Institute of Nuclear Medical Physics,University of Science and Technology of China,Hefei 230026,China)

机构地区：[1]郑州大学第一附属医院放射治疗部,郑州450052 [2]中国科学技术大学核科学技术学院,合肥230026

出　　处：《中华放射肿瘤学杂志》2022年第12期1185-1189,共5页Chinese Journal of Radiation Oncology

基　　金：河南省高等学校重点科研项目(23B320004);河南省医学科技攻关计划省部共建青年项目(SBGJ202103073);中华国际医学交流基金会肿瘤精准放疗星火计划临床科研基金(HDRS2020010110);河南省医学科技攻关计划联合共建项目(LHGJ20190161);河南省青年自然科学基金(212300410288)。

摘　　要：皮肤T细胞淋巴瘤是一组相对罕见的主要表现在皮肤的成熟T细胞淋巴瘤,其常见的亚型是蕈样肉芽肿(俗称蕈样霉菌病)。电子线全身照射作为重要的常规治疗手段之一,却存在着剂量分布不均、体位重复差、治疗时间过长等诸多缺点,从而影响疗效及患者预后。近年随着螺旋断层放疗系统的出现与逐步普及,越来越多的单位凭借其能治疗超长靶区和实现剂量雕刻式分布的特点,正逐步扩展其在全身皮肤照射治疗中的应用,以便进一步探讨其优劣并确认是否能取代传统电子线全身照射。本文对螺旋断层全身皮肤照射治疗的研究进展做一综述,介绍其治疗技术的发展、临床治疗效果及目前存在的顾虑和争议。Cutaneous T‐cell lymphomas are a relatively rare group of mature T‐cell lymphomas mainly manifesting in the skin,and its common subtype is mycosis fungoides.Total skin electron irradiation is one of the important conventional treatment methods,but there are many disadvantages,such as uneven dose distribution,poor position repetition,and long treatment time,which affect the clinical efficacy and patient prognosis.With the emergence and gradual popularization of helical tomotherapy in recent years,more and more medical institutions are gradually expanding their applications in total skin irradiation due to their ability to treat ultra‐long targets and achieve dose‐sculpted distribution,aiming to further explore its good or bad,and confirm whether it can replace the traditional total skin electron irradiation.In this article,research progress on total skin irradiation using helical tomotherapy was reviewed,the development of treatment technology,clinical efficacy and current concerns and controversies were illustrated.

关 键 词：螺旋断层放射疗法 全身皮肤照射 皮肤T细胞淋巴瘤 蕈样霉菌病 

分 类 号：R739.5[医药卫生—肿瘤] R730.55[医药卫生—临床医学]