阿尔茨海默病患者认知功能损害与氧化应激的关系分析  

Analysis of Relationship between Cognitive Impairment and Oxidative Stress in Patients with Alzheimer’s Disease

作　　者：张泓娇 杨玉超[1] 张晓琳[1] ZHANG Hongjiao;YANG Yuchao;ZHANG Xiaolin(General Hospital of Fushun Mining Bureau of Liaoning Health Industry Group,Fushun 113008,Liaoning Province,China)

机构地区：[1]辽宁健康产业集团抚顺矿务局总医院,辽宁抚顺113008

出　　处：《中国实用乡村医生杂志》2022年第9期70-73,共4页Chinese Practical Journal of Rural Doctor

摘　　要：目的探讨阿尔茨海默病患者认知功能损害与氧化应激的关系。方法选择2020年6月—2022年6月辽宁健康产业集团抚顺矿务局总医院收治的127例阿尔茨海默病患者为研究组,选择同期来我院体检的40例老年人为对照组,同时依据临床痴呆评定量表将研究组分为轻、中、重度3个亚组,对研究组与对照组以及研究组各亚组间氧化应激指标进行比较。结果研究组超氧化物歧化酶和谷胱甘肽过氧化物酶水平低于对照组,铜蓝蛋白、活性氧、4-羟基壬烯酸、同型半胱氨酸、血尿酸水平高于对照组,差异均有统计学意义(P<0.05)。亚组分析显示,重度组超氧化物歧化酶和谷胱甘肽过氧化物酶水平最低,铜蓝蛋白、活性氧、4-羟基壬烯酸、同型半胱氨酸、血尿酸水平最高,各亚组间氧化应激指标差异均有统计学意义(P<0.05)。结论阿尔茨海默病患者的认知功能损害与氧化应激有关,认知功能损害越重氧化应激失衡越明显。Objective To explore the relationship between cognitive impairment and oxidative stress in patients with Alzheimer’s disease(AD).Methods A total of 127 AD patients admitted to General Hospital of Fushun Mining Bureau of Liaoning Health Industry Group from June 2020 to June 2022 were selected as the study group,and 40 elderly people who came to our hospital for physical examination in the same period were selected as the control group.According to the clinical dementia rating scale,the study group was divided into three subgroups:mild,moderate and severe.The oxidative stress indicators between the study group and the control group,as well as among the subgroups of the study group were compared.Results The levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in the study group were significantly lower than those in the control group,while the levels of ceruloplasmin(CP),reactive oxygen species(ROS),4-hydroxynonenoic(4-HNE),homocysteine(Hcy)and serum uric acid(SUA)were significantly higher than those in the control group(all P<0.05).Subgroup analysis showed that in severe group,the levels of SOD and GSH-Px were the lowest,while the levels of CP,ROS,4-HNE,Hcy,and SUA were the highest,there were significant differences in oxidative stress indicators among the subgroups(P<0.05).Conclusion There is a certain relationship between cognitive impairment and oxidative stress in AD patients,the more severe the cognitive impairment,the more obvious the imbalance of oxidative stress.

关 键 词：阿尔茨海默病 认知功能 氧化应激 关系 

分 类 号：R74[医药卫生—神经病学与精神病学]