6494例妇科门诊病人子宫颈人乳头瘤病毒基因型分析  

Analysis of cervical HPV genotypes in 6494 gynecological outpatients

作　　者：孔评石[1] 毛洁[2] 王生余 KONG Ping-shi;MAO Jie;WANG Sheng-yu(Department of Clinical Laboratory,The Second Traditional Chinese Medicine Hospital of Jiangsu,NanjingJiangsu 210017,China;Department of Obstetrics andGynecology,The Second Traditional Chinese Medicine Hospital of Jiangsu,NanjingJiangsu 210017,China)

机构地区：[1]江苏省第二中医院检验科,江苏南京210017 [2]江苏省第二中医院妇产科,江苏南京210017

出　　处：《蚌埠医学院学报》2022年第12期1715-1719,共5页Journal of Bengbu Medical College

基　　金：南京中医药大学第二附属医院院级课题(SEZ2019021)。

摘　　要：目的:分析南京地区妇科门诊病人感染宫颈人乳头瘤病毒(HPV)基因型的分布特征,为宫颈癌的防治提供支持。方法:通过医院信息系统采集数据,分析妇科门诊经宫颈脱落细胞HPV基因型检测的病人6494例相关数据。结果:6494例受试病人中HPV感染阳性1882例,阳性率为28.98%。不同年龄组HPV感染阳性率间差异有统计学意义(P<0.01),其中≤19岁组HPV感染阳性率为74.70%(62/83),均高于其他年龄组(P<0.05)。受试病人以单一HPV感染(1199/6494,18.46%)为主,不同年龄段病人的单一HPV感染率间差异无统计学意义(P>0.05),而双重和多重HPV感染率间差异均有统计学意义(P<0.01)。受试病人以高危型HPV感染率为主(21.96%,1426/6494);24种基因型的HPV中,总体感染率排名前5位依次为HPV52、HPV16、HPV58、HPV51、HPV42,其中除HPV35感染率在各年龄组间差异无统计学意义外(P>0.05),其他各HPV基因型感染率在不同年龄组间差异均有统计学意义(P<0.05~P<0.01)。结论:通过明确当地门诊病人的HPV感染基因型分布特征,可为宫颈癌的治疗和预防提供一定参考依据。Objective:To analyze the distribution characteristics of cervical human papillomavirus(HPV)genotypes in gynecological outpatients in Nanjing,so as to provide support for the prevention and treatment of cervical cancer.Methods:The data of 6494 patients with HPV genotype detected by cervical exfoliated cells in gynecological clinic were analyzed by collecting data from hospital information system.Results:A total of 1882 of 6494 patients were positive for HPV infection,and the positive rate was 28.98%.There was significant difference in the positive rate of HPV infection among different age groups(P<0.01).The positive rate of HPV infection in the group≤19 years old was 74.70%(62/83),which was higher than that in other age groups(P<0.05).The main patients were single HPV infection(1199/6494,18.46%).There was no significant difference in the rate of single HPV infection among patients of different ages(P>0.05),but there was significant difference in the rate of double and multiple HPV infection(P<0.01).The infection rate of high-risk HPV was the main type of patients(21.96%,1426/6494).Among the 24 genotypes of HPV,the top five overall infection rates were HPV52,HPV16,HPV58,HPV51 and HPV42.There was no significant difference in HPV35 infection rate among different age groups(P>0.05),but the infection rate of other HPV genotypes had statistical significance among different age groups(P<0.05 to P<0.01).Conclusions:By clarifying the genotype distribution characteristics of HPV infection in local outpatients,it can provide a certain reference basis for the treatment and prevention of cervical cancer.

关 键 词：子宫颈癌 人乳头瘤病毒 基因型 

分 类 号：R737.33[医药卫生—肿瘤]