lncRNA OVAAL、miR-335、TRIM 14在子宫内膜癌中表达及与临床特征相关性研究  

Expression of lncRNA OVAAL,miR-335 and TRIM 14 in endometrial cancer and its correlation with clinical characteristics

作　　者：郭丽宁 常蕊[1] 杨杰 李惠 GUO Li-ning;CHANG Rui;YANG Jie;LI Hui(Department of Obstetrics and Gynecology,the First Hospital of Yulin City,Shaanxi Province,Yulin 719000,China)

机构地区：[1]陕西省榆林市第一医院妇产科,陕西榆林719000

出　　处：《河北医科大学学报》2023年第1期68-73,111,共7页Journal of Hebei Medical University

基　　金：榆林市科技计划项目(YF-2020-032)。

摘　　要：目的探讨卵巢腺癌扩增长非编码RNA(long non-coding RNA,lncRNA OVAAL)、微小RNA(microRNA,miR)-335、三重基序蛋白14(tripartite motif 14,TRIM 14)在子宫内膜癌(endometrial cancer,EC)中表达及与临床特征相关性。方法选取我院EC患者86例作为癌组织组,同期子宫内膜息肉(endometrial polyps,EP)患者86例作为EP组织组。检测EC癌组织、癌旁组织及EP组织lncRNA OVAAL、miR-335、TRIM14表达,分析其与EC临床特征间关系及对EC复发风险的预测价值。结果癌组织组lncRNA OVAAL、TRIM14表达高于癌旁组织组、EP组织组,miR-335表达低于癌旁组织组、EP组织组(P<0.05),EP组织组lncRNA OVAAL、TRIM14表达高于癌旁组织组,miR-335表达低于癌旁组织组(P<0.05);癌组织lncRNA OVAAL、miR-335、TRIM14表达与FIGO分期、组织学分级、肌层浸润深度、淋巴结转移、血管侵犯、病理类型有关(P<0.05);复发患者癌组织lncRNA OVAAL、TRIM14表达高于未复发患者,miR-335表达低于未复发患者(P<0.05);校正FIGO分期、组织学分级、肌层浸润深度、淋巴结转移、血管侵犯、淋巴结清扫范围后,lncRNA OVAAL、miR-335、TRIM14表达为EC复发的影响因素(P<0.05);lncRNA OVAAL、miR-335、TRIM14联合预测EC复发的曲线下面积大于单一指标预测值。结论癌组织lncRNA OVAAL、miR-335、TRIM14表达异常,且与EC患者FIGO分期、组织学分级、肌层浸润深度、淋巴结转移、血管侵犯、病理类型等特征有关,可作为预测术后复发的重要指标。Objective To investigate the expression of ovarian adenocarcinoma amplified long non-coding RNA(lncRNA OVAAL),microRNA(miR)-335 and tripartite motif 14(TRIM14)in endometrial carcinoma(EC)and their correlation with clinical characteristics.Methods A total of 86 EC patients in our hospital were selected as the case group,and 86 patients with endometrial polyps(EP)during the same period were selected as the control group.The expressions of lncRNA OVAAL,miR-335 and TRIM14 in EC cancer tissues,adjacent tissues and endometrial polyps were detected.Their relationship with clinical characteristics of EC and their predictive value for the risk of EC recurrence were analyzed.Results The expression of lncRNA OVAAL and TRIM14 in cancer tissue was higher than that in adjacent tissue and EP tissue,while the expression of miR-335 was lower than that in adjacent tissue and EP tissue(P<0.05).The expression of lncRNA OVAAL and TRIM14 in EP tissues was higher than that in adjacent tissue,and the expression of miR-335 was lower than that in adjacent tissue(P<0.05).The expression of lncRNA OVAAL,miR-335 and TRIM14 in cancer tissue was related to FIGO stage,histological grade,depth of myometrial invasion,lymph node metastasis,vascular invasion,and pathological type(P<0.05).The expression of lncRNA OVAAL and TRIM14 in cancer tissues of patients with recurrence was higher than that of patients without recurrence,and the expression of miR-335 was lower than that of patients without recurrence(P<0.05).After adjusting for FIGO stage,histological grade,depth of myometrial invasion,lymph node metastasis,vascular invasion,and extent of lymph node dissection,the expression of lncRNA OVAAL,miR-335 and TRIM14 were the influencing factors of EC recurrence(P<0.05).The AUC of lncRNA OVAAL,miR-335 and TRIM14 combined to predict EC recurrence was greater than that of single index.Conclusion The abnormal expression of lncRNA OVAAL,miR-335 and TRIM14 in cancer tissue is related to FIGO stage,histological grade,depth of myometrial invasion,lymph node me

关 键 词：子宫内膜癌 非编码RNA 子宫内膜息肉 三重基序蛋白 

分 类 号：R730.26[医药卫生—肿瘤]