子宫内膜癌组织中Ki-67、p16蛋白的表达及其对手术治疗预后的评估价值  

Analysis on Expression of Ki-67 and p16 Protein in Tissues of Patients with Endometrial Carcinoma and Their Evaluation of Prognosis After Surgical Treatment

作　　者：司小丽 苏宝珍 SI Xiaoli;SU Baozhen(Changge People's Hospital,Xuchang,461500)

机构地区：[1]河南省长葛市人民医院,461500

出　　处：《实用癌症杂志》2023年第1期16-20,共5页The Practical Journal of Cancer

摘　　要：目的 观察子宫内膜癌(EC)组织中增殖细胞核抗原-67(Ki-67)、抑癌基因p16蛋白表达,分析EC组织中Ki-67、p16蛋白表达对手术治疗预后的评估价值。方法 选择137例实施手术治疗的EC患者作为研究对象,收集患者的EC组织,检测Ki-67、p16在EC组织中的表达,随访2年,评估患者预后(复发、转移发生)情况,比较不同预后EC患者基线资料、实验室指标,重点分析EC患者组织中Ki-67、p16蛋白表达对手术治疗预后的预测。结果 随访2年,137例EC患者中17例复发,4例转移,预后不良发生率为15.33%(21/137)。经Logistic回归分析结果显示,国际妇产科协会(FIGO)分期高、Ki-67表达高可能是EC患者淋巴结转移的风险因子(OR>1,P<0.05),p16表达高可能是EC患者手术治疗预后的保护因子(OR<1,P<0.05)。绘制ROC曲线图,结果显示,Ki-67、p16蛋白表达预测EC患者手术治疗预后不良的AUC分别为0.833、0.827,均有一定预测价值;绘制决策曲线结果显示,在阈值0.2~1.0范围内,联合子宫内膜癌患者组织中Ki-67、p16蛋白表达预测EC患者手术治疗预后不良的净受益率优于单独某一指标,且在高风险阈值0.0~1.0内的净受益率始终大于0,始终有临床意义,净受益率最大值为0.153。结论 子宫内膜癌组织中Ki-67、p16蛋白表达与手术治疗预后有关,用于预测预后不良具有一定的价值,且联合预测获得的净受益率更高。Objective To observe the expression of proliferating cell nuclear antigen-67(Ki-67) and tumor suppressor gene p16 protein in tissues of endometrial carcinoma(EC),to analyze the evaluation value of Ki-67 and p16 protein expression in tissues of EC on prognosis of surgical treatment.Methods 137 patients with EC who underwent surgical treatment were selected as the research subjects, collected the EC tissues of patients, the expressions of Ki-67 and p16 in EC tissues were detected, the patients were followed up for 2 years to evaluate their prognosis(recurrence and metastasis),the baseline data and laboratory indexes of EC patients with different prognosis were compared, the expression of Ki-67 and p16 protein in EC patients and the prediction on prognosis of surgical treatment were mainly analyzed.Results Followed for 2 years, 17 of 137 patients with EC in this study had recurrence and 4 had metastasis, the incidence of poor prognosis was 15.33%(21/137).The results of Logistic regression analysis showed that, high International Federation of Gynecology and Obstetrics(FIGO) stage and high Ki-67 expression might be risk factors for lymph node metastasis in EC patients(OR>1,P<0.05),p16 might be a protective factor for the prognosis of EC patients after surgical treatment(OR<1,P<0.05).The ROC curve was drawn, and the results showed that, the AUC of Ki-67 and p16 protein expression in predicting the poor prognosis of EC patients after surgical treatment were 0.833 and 0.827,respectively, which had certain predicting value;the decision curve was drawn and the results showed that, within the threshold range of 0.2~1.0,the net benefit rate of combining the expression of Ki-67 and p16 protein in tissues of endometrial cancer patients in predicting poor prognosis of EC patients after surgical treatment was better than a single index, the net benefit rate within the high-risk threshold of 0.0~1.0 was always greater than 0,which was always clinically significant, and the maximum net benefit rate was 0.153.Conclusion The expres

关 键 词：子宫内膜癌 增殖细胞核抗原-67 抑癌基因P16 预后 

分 类 号：R737.33[医药卫生—肿瘤]