腹腔镜下广泛子宫切除术治疗宫颈癌的临床效果及对血清肿瘤标志物的影响  

Clinical Effect of Laparoscopic Extensive Hysterectomy for Cervical Cancer and Its Influence on Serum Tumor Markers

作　　者：王玉 李莉[2] 胡莉[1] WANG Yu;LI Li;HU Li(The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第五附属医院,450000 [2]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2023年第1期46-48,55,共4页The Practical Journal of Cancer

摘　　要：目的 分析腹腔镜下广泛子宫切除术(LRH)对宫颈癌患者的治疗效果。方法 选取74例宫颈癌患者,按随机数字表法分为两组,各37例。对照组行开腹广泛子宫切除术(ARH),观察组则行LRH,观察到术后3个月。对比两组手术相关指标、血清肿瘤标志物、TH1、TH2细胞因子、盆底功能、并发症。结果 观察组术中出血量少于对照组,手术、肛门排气与住院时间短于对照组,并发症发生率低于对照组,有统计学差异(P<0.05);术后,观察组癌胚抗原(CEA)、糖类抗原125(CA125)、INF-γ、TNF-α、IL-6、IL-10水平低于对照组,PFDI-20评分低于对照组。结论 LRH在宫颈癌患者治疗中效果确切,创伤性更小,可促进患者更快的恢复,有效降低血清肿瘤标志物水平,且对机体的免疫系统影响较小,并发症较少,有助于改善盆底功能。Objective To analyze the therapeutic effect of laparoscopic extensive hysterectomy(LRH) on cervical cancer.Methods 74 patients with cervical cancer were randomly divided into 2 groups, 37 cases in each group.The control group received laparotomy extensive hysterectomy(ARH),and the observation group received LRH,which was observed 3 months after the operation.The operation related indexes, serum tumor markers, TH1,TH2 cytokines, pelvic floor function, and complications were compared between the 2 groups.Results The amount of bleeding during operation in the observation group was less than that in the control group, and the time of operation, anus exhaust and hospitalization was shorter than that in the control group.The incidence of complications in the observation group was lower than that in the control group, with statistical difference(P<0.05);After operation, carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),INF-γ、 TNF-α、 The level of IL-6 and IL-10 was lower than that of the control group, and the PFDI-20 score was lower than that of the control group.Conclusion LRH is effective in the treatment of cervical cancer, less traumatic, can promote faster recovery of patients, effectively reduce the level of serum tumor markers, and has less impact on the immune system and fewer complications, which is helpful to improve pelvic floor function.

关 键 词：宫颈癌 开腹广泛子宫切除术 盆底功能 免疫系统 

分 类 号：R737.33[医药卫生—肿瘤]