复杂性肝癌手术治疗的效果及相关影响因素分析  

Analysis of the Effect and Related Influencing Factors

作　　者：巴雪 裴理辉[1] 柴宇霞[1] BA Xue;PEI Lihui;CHAI Yuxia(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2023年第1期92-94,共3页The Practical Journal of Cancer

摘　　要：目的 分析复杂性肝癌切除术治疗效果及相关影响因素。方法 选取90例复杂性肝癌患者。所有患者均行肝癌切除术,术后随访2年,统计患者生存情况,按照生存情况分为生存组和死亡组,收集患者一般临床资料,并采用单因素及多因素Logistic分析分析影响患者生存的相关影响因素。结果 两组性别、年龄、术前Child-Pugh分级、术前甲胎蛋白(AFP)、乙肝表面抗原(HBsAg)、胆管癌栓、第一肝门阻断次数、麻醉时间、术中输血量比较,差异无统计学意义(P>0.05);生存组中度或重度肝硬化、肿瘤最大直径>5 cm、合并门静脉癌栓、术中出血量>700 ml比率低于死亡组,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,中度或重度肝硬化、肿瘤最大直径>5 cm、合并门静脉癌栓、术中出血量>700 ml均是复杂性肝癌切除术后生存情况的独立危险因素。结论 中度或重度肝硬化、肿瘤最大直径>5 cm、合并门静脉癌栓、术中出血量>700 ml均是复杂性肝癌切除术后生存情况的独立危险因素,对于存在上述高危因素患者应密切随访,以便及时发现肿瘤转移和复发,并及时采取治疗措施,提高患者生存率。Objective To analyze the treatment effect of complicated liver cancer resection and the related influencing factors.Methods 90 patients with complicated liver cancer were selected.All patients underwent liver cancer resection and were followed up for 2 years after surgery.Patient survival was counted and divided into survival group and death group according to survival conditions.General clinical data were collected, and relevant influencing factors affecting patient survival were analyzed by univariate and multivariate Logistic analysis.Results Comparison of gender, age, preoperative Child-Pugh grade, preoperative alpha-fetoprotein(AFP),hepatitis B surface antigen(HBsAg),cholangiocarcinoma thrombus, number of first hepatic hilar block, time of anesthesia, and intraoperative blood transfusion, There was no significant difference(P>0.05);The ratio of moderate or severe liver cirrhosis, maximum tumor diameter> 5 cm, combined portal vein cancer thrombus, intraoperative blood loss> 700 ml was lower than that in the survival group, The difference was statistically significant(P<0.05);The multivariate Logistic regression analysis showed that, Moderate or severe liver cirrhosis, maximum tumor diameter> 5 cm, combined portal vein cancer thrombus, and intraoperative blood loss> 700 ml were all independent risk factors for survival after complex liver cancer resection.Conclusion Moderate or severe cirrhosis, tumor maximum diameter> 5 cm, combined portal vein cancer thrombus, intraoperative bleeding> 700 ml are the independent risk factors of survival after complex liver cancer resection, for the risk factors should be close follow-up, in order to timely find tumor metastasis and recurrence, and timely treatment measures, improve the survival rate of patients.

关 键 词：肝癌 复杂性肝癌切除术 影响因素 

分 类 号：R735.7[医药卫生—肿瘤]