超级增强子区域遗传变异与乙型肝炎病毒相关肝细胞癌术后总生存期的关联分析  

Association of genetic variants of super-fnhancer region with survival of HBV-related hepatocellular carcinoma

作　　者：韦雪艳 林秋伶 邱模勤 陈佩琴 周子寒 刘颖春 梁伟康 张若昕 余红平[1] WEI Xueyan;LIN Qiuling;QIU Moqin;CHEN Peiqin;ZHOU Zihan;LIU Yingchun;LIANG Weikang;ZHANG Ruoxin;YU Hongping(School of Public Health,Guangxi Medical University,Nanning 530021,China;不详)

机构地区：[1]广西医科大学公共卫生学院,南宁530021 [2]广西医科大学附属肿瘤医院,南宁530021 [3]复旦大学公共卫生学院流行病学教研室,上海200032

出　　处：《实用医学杂志》2022年第24期3059-3064,共6页The Journal of Practical Medicine

基　　金：广西重点研发计划(编号:桂科AA18221001);广西自然科学基金重点项目(编号:2018GXNSFDA050012);广西壮族自治区卫生健康委员会肿瘤分子医学重点(培育)实验室(编号:ZPTJ2020001);区域高发肿瘤防治教育部/广西重点实验室自主研究项目(编号:GKE-ZZ202104);区域高发肿瘤防治教育部/广西重点实验室开放课题(编号:GKE-KF202102);区域高发肿瘤防治教育部/广西重点实验室自主研究项目(编号:GKE-ZZ202118);广西医疗卫生适宜技术开放与推广应用项目(编号:S2021022)。

摘　　要：目的探讨超级增强子区域遗传变异与乙型肝炎病毒(HBV)相关肝细胞癌(hepatocellular carcinoma,HCC)术后患者总生存期(overall survival,OS)的关系。方法以2007年7月至2017年12月于广西医科大学附属肿瘤医院行肝癌切除术的866例HCC患者为研究对象,采用Cox比例风险模型、KaplanMeier法分析超级增强子区域遗传变异与患者OS的关系。结果rs61805159(G>A)和rs4791170(G>A)的A等位基因均可增加HCC患者死亡风险(均P<0.001),rs546220(C>A)A等位基因降低HCC患者死亡风险(P<0.001)。而且,携带多个风险基因型较携带0个风险基因型的患者生存率降低,死亡风险更大,存在剂量-反应关系(Ptrend<0.001)。结论超级增强子区域单个或多个遗传变异位点影响HCC患者OS。Objective To investigate the relationship between genetic variation of super-enhancer region and overall survival(OS)of postoperative patients with hepatitis B virus(HBV)related hepatocellular carcinoma(HCC).Methods A total of 866 patients HCC who underwent hepatectomy in Guangxi Medical University Cancer Hospital from July 2007 to December 2017 were studied.The relationship between genetic variation of super enhancer region and OS were analysed using Kaplan-Meier analysis and Cox proportional hazards regression model.Results The rs61805159(G>A)and rs4791170(G>A)A allele were associated with higher risk of death in patients with HCC(P<0.001),whereas rs546220(C>A)A allele was associated with a lower risk of death(P<0.001).Moreover,patients with multiple risk genotypes had a lower survival rate and a higher risk of death mortality risk than those with 0 risk genotypes,and there was a dose-response relationship(Ptrend<0.001).Conclusion Single or multiple genetic variation of loci in the super-enhancer region affected OS of patients with HCC.

关 键 词：肝癌 预后 超级增强子 单核苷酸多态性 

分 类 号：R735.7[医药卫生—肿瘤]