糖代谢状况与抑郁症患病关系研究  

Associations between Depressive Disorder and Glycometabolism Status

作　　者：王鹏[1] 王思齐[1] 杨璐[1] 叶逦阳 魏爽爽 陈乐 章伟 WANG Peng;WANG Siqi;YANG Lu(Ningxia Medical University,Yinchuan City,Ningxia 750004;不详)

机构地区：[1]宁夏医科大学,宁夏银川市750004 [2]浙江省皮肤病医院

出　　处：《医学理论与实践》2023年第1期14-17,13,共5页The Journal of Medical Theory and Practice

基　　金：国家自然科学基金青年基金项目(82001282);国家自然科学基金地区科学基金项目(81960232);宁夏重点研发计划项目(2019BEB04041);宁夏青年科技人才托举工程(TJGC2019081);宁夏医科大学青年人才项目(XT2019018);宁夏留学回国人员创新创业个人项目(2021-04)。

摘　　要：目的:探讨糖代谢状况与抑郁症患病的关系。方法:选择美国国家健康和营养调查(NHANES)2017-2018年度调查中开展了抑郁症筛查(患者健康问卷-9,PHQ-9)且同时进行了糖代谢指标测定(空腹血糖、糖化血红蛋白、空腹胰岛素、胰岛素抵抗指数)的美国成年人群作为研究对象,将该人群按照PHQ-9评分(总分0~27分)分为抑郁症组(PHQ-9评分≥10分)和非抑郁症组(PHQ-9评分<10分),通过秩和检验比较其糖代谢状况差异,使用二分类Logistic回归模型分析糖代谢状况与抑郁症患病关系。结果:2299例纳入研究的对象年龄中位数为52(34~62)岁,其中男性1124名(48.89%),抑郁症病例为221名(9.61%)。抑郁症组和非抑郁症组在糖化血红蛋白、空腹胰岛素、胰岛素抵抗指数方面存在统计学差异(P<0.05),但在空腹血糖方面无统计学差异(P>0.05)。二分类Logistic回归分析调整性别、年龄组、种族、文化程度、婚姻状况、体质指数等混杂因素后,抑郁症患病与糖化血红蛋白、空腹胰岛素及胰岛素抵抗指数相关[OR(95%CI)分别为1.240(1.114~1.381)、1.007(1.002~1.012)、1.020(1.009~1.031)]。结论:抑郁症患病与糖代谢状况存在相关性。Objective:To explore the relationship between depressive disorder and glycometabolism status.Methods:American adults conducted with depressive disorder survey[Patient Health Questionnaire 9(PHQ-9)test]and glycometabolism assessment including fasting plasma glucose(FPG),glycated hemoglobin(GH),fasting insulin(FINS)and insulin resistance index(HOMA-IR),were included as the research participants from American NHANES 2017-2018.The participants were divided into depressive disorder group(PHQ-9 score≥10)and group without depressive disorder(PHQ-9 score<10)according to PHQ 9 scores(0~27 points),then compared the differences of glycometabolism indicators with rank sum test,and further analyzed the relationships of depressive disorder with glycometabolism indicators,by binary logistic regression models.Results:A total of 2299 persons were included in the study,including 1124 males(48.89%),with a median age of 52(34~62)years old.The depressive disorder cases accounted for 9.61%(221 cases).There were statistical differences in GH,FINS and HOMA-IR between depressive disorder group and group without it(P<0.05).Whereas there was no statistical difference in FPG between them(P<0.05).Binary Logistic regression analysis showed that GH,FINS and HOMA-IR were associated with depressive disorder after adjustment for age group,sex,education level,marital status,race and body mass index[OR(95%CI):1.240(1.114~1.381),1.007(1.002~1.012),1.020(1.009~1.031)].Conclusion:Depressive disorder is associated with glycometabolism status.

关 键 词：抑郁症 糖代谢 LOGISTIC回归分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]