低角膜内皮细胞密度患者角膜后表面高阶像差的特点  

Characteristics of posterior corneal surface higher-order aberrations in patients with low-corneal endothelial cells density

作　　者：钱道卫[1] 牛勇毅[2] 张洪洋[2] 廖燕秋 李远存 QIAN Dao-wei;NIU Yong-yi;ZHANG Hong-yang;LIAO Yan-qiu;LI Yuan-cun(Department of Ophthalmology,Pingshan District People′s Hospital of Shenzhen/Pingshan General Hospital of Southern Medical University,Shenzhen 518118,Guangdong,China;Department of Ophthalmology,Guangdong General Hospital,Guangzhou 510080,Guangdong,China)

机构地区：[1]深圳市坪山区人民医院/南方医科大学坪山总医院眼科,广东省深圳市518118 [2]广东省人民医院眼科,广东省广州市510080

出　　处：《广西医学》2022年第22期2600-2603,共4页Guangxi Medical Journal

基　　金：广东省深圳市坪山区卫生系统科研项目(202053)。

摘　　要：目的分析低角膜内皮细胞密度(ECD)患者角膜后表面高阶像差的特点。方法选取角膜ECD<1000个/mm^(2)的16例(18眼)白内障患者作为低角膜ECD组,将角膜ECD为2000~2500个/mm^(2)的20例(20眼)白内障患者作为对照组。比较两组患者角膜内皮细胞参数[包括角膜ECD、细胞面积变异系数(CV)]、角膜厚度和角膜后表面像差(包括总像差、总高阶像差、3阶像差、4阶像差、5阶像差、彗差、三叶草像差、球差)。分析角膜ECD、角膜厚度与角膜后表面高阶像差的相关性。结果低角膜ECD组患者的角膜ECD少于对照组,细胞面积CV大于对照组(均P<0.05),而两组角膜厚度差异无统计学意义(P>0.05)。低角膜ECD组的总像差、总高阶像差、3阶像差、4阶像差、5阶像差、三叶草像差均高于对照组(均P<0.05),而两组的球差和彗差差异均无统计学意义(均P>0.05)。两组角膜ECD与总高阶像差、3阶像差、4阶像差、5阶像差、彗差、三叶草像差、球差均无相关性(均P>0.05)。除对照组角膜厚度与4阶像差呈负相关外(P<0.05),两组的角膜厚度与总高阶像差、3阶像差、5阶像差、彗差、三叶草像差、球差均无相关性(均P>0.05)。结论低角膜ECD患者角膜后表面高阶像差增大。虽然角膜ECD与角膜后表面各高阶像差无明显相关性,但在为低角膜ECD患者行白内障手术时应考虑角膜后表面高阶像差,选择适合的人工晶状体,以提高患者术后视觉质量。Objective To analyze the characteristics of posterior corneal surface higher-order aberrations in patients with low-corneal endothelial cells density(ECD).Methods A total of 16 cataract patients(18 eyes)whose corneal ECD were less than 1000 cells/mm^(2) were selected as low-corneal ECD group,and 20 cataract patients(20 eyes)with corneal ECD between 2000 and 2500 cells/mm^(2) as control group.The corneal endothelial cells parameters as for corneal ECD and coefficient of variation(CV)in cell areas,corneal thickness,and posterior corneal surface aberrations(total aberration,total high-order aberration,3-order aberration,4-order aberration,5-order aberration,comatic aberration,trefoil aberration,and spherical aberration)were compared between the two groups.The correlation of corneal ECD and corneal thickness with posterior corneal surface high-order aberrations was analyzed.Results The low-corneal ECD group exhibited a less corneal ECD,and a larger CV in cell areas as compared with the control group(all P<0.05),whereas no statistically significant difference in corneal thickness was found between the two groups(P>0.05).The low-corneal ECD group exhibited higher total aberration,total high-order aberration,and 3-,4-,and 5-order aberrations,as well as trefoil aberration as compared with the control groups(all P<0.05),whereas no statistically significant difference in spherical and comatic aberrations was found between the two groups(all P>0.05).No correlation of corneal ECD with total high-order aberration,and 3-,4-,and 5-order aberrations,as well as comatic aberration,trefoil aberration,and spherical aberration was found between the two groups(all P>0.05).Except for the corneal thickness negatively correlated with 4-order aberration in the control groups(P<0.05),no correlation of corneal thickness with total high-order aberration,and 3-,and 5-order aberrations,as well as comatic aberration,trefoil aberration,and spherical aberration was found between the two groups(all P>0.05).Conclusion The posterior corneal surface

关 键 词：低角膜内皮细胞密度 角膜后表面 高阶像差 

分 类 号：R779.6[医药卫生—眼科]