抗神经抗体在神经精神狼疮中的研究进展  

Research Progress in Antibodies Related to Autoimmune Encephalitis in Neuropsychiatric Systemic Lupus Erythematosus

作　　者：陈思娴 任海涛[1] 曾小峰[2] 关鸿志[1] CHEN Sixian;REN Haitao;ZENG Xiaofeng;GUAN Hongzhi(Department of Neurology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Rheumatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院神经科,北京100730 [2]中国医学科学院北京协和医院风湿免疫科,北京100730

出　　处：《罕见病研究》2022年第2期217-222,共6页Journal of Rare Diseases

基　　金：中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-003);国家重点研发计划(2021YFC2501300)。

摘　　要：抗神经抗体是神经精神狼疮(NPSLE)潜在的诊断标志物之一,这些抗神经抗体包括抗神经元抗体与抗神经胶质细胞抗体。抗神经元抗体又分为抗神经元表面蛋白抗体和其他抗神经元细胞内蛋白抗体,前者以抗N-甲基-D-天冬氨酸受体(NMDAR)抗体为代表。本文对NPSLE相关抗神经抗体进行分类阐述。Several anti-neural antibodies are associated with neuropsychiatric systemic lupus erythematosus(NPSLE)including anti-neuronal antibodies and anti-glial cell antibodies.The anti-neuronal antibodies has two types:anti-neuronal surface protein antibodies represented by anti-N-methyl-D-aspartate receptor(NMDAR)antibodies,and anti-neuronal intracellular protein antibodies.In this paper,we review and classify the anti-neural antibodies related to NPSLE.

关 键 词：系统性红斑狼疮 神经系统 神经精神狼疮 抗神经抗体 抗神经元抗体 抗神经胶质细胞抗体 

分 类 号：R743[医药卫生—神经病学与精神病学]