Linking B cell metabolism to immune regulation:the neurotransmitter GABA  

作　　者：Yang Shi 

机构地区：[1]Institute for Experimental Molecular Imaging,Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering,Faculty of Medicine,RWTH Aachen University,Aachen 52074,Germany

出　　处：《Signal Transduction and Targeted Therapy》2022年第9期3143-3144,共2页信号转导与靶向治疗（英文）

基　　金：Y.Shi receives funding support from the European Research Council(ERC Starting Grant,101040996);the German Research Foundation(DFG,SH 1223/1-1);the Excellence Strategy of the Federal Government and the Lander(Project(DE-82)EXS-SF-OPSF580).

摘　　要：In a recent study published in Nature,1Zhang et al.reported that activated B cells produced and released the principal inhibitory neurotransmitter y-aminobutyric acid(GABA).The GABA secretion was demonstrated to inhibit cancer immunity by suppressing cytotoxic T cells and macrophages.The study revealed a new immune regulation mechanism of B cells,which suggests a new direction to understand cancer immunity and develop immunotherapeutics.

关 键 词：IMMUNITY METABOLISM al. 

分 类 号：R392[医药卫生—免疫学]