Caspase-7 and acid sphingomyelinase:partner repairmans of gasdermin and perforin pores  

作　　者：Ke Jin Guofang Shen 

机构地区：[1]Laboratory of Human Diseases and Immunotherapies,West China Hospital,Sichuan University,610041 Chengdu,China [2]Institute of Immunology and Inflammation,Frontiers Science Center for Disease related Molecular Network,West China Hospital,Sichuan University,610041 Chengdu,China [3]Department of Hematologic Malignancies Translational Sciences,Beckman Research Institute of City of Hope,Duarte,CA 91010,USA

出　　处：《Signal Transduction and Targeted Therapy》2022年第9期3172-3173,共2页信号转导与靶向治疗（英文）

基　　金：This work was supported by the Chinese National Natural Science Funds(81902947).

摘　　要：Recently,a work published in Nature by Kengo Nozaki et al.revealed a novel mechanism for plasma membrane pores'repair mediated by caspase-7.In this work,they found caspase-7 facilitated Intestinal epithelial cell(IEC)extrusion and repaired gasdermin D(GSDMD)and perforin pores via activating acid sphingomyelinase(ASM).The pores repair mechanism mediated by caspase-7 is independent of caspase-3 activity(Fig.1).

关 键 词：MYELIN al. pores 

分 类 号：R392[医药卫生—免疫学]