胞二磷胆碱注射液联合盐酸美金刚治疗血管性痴呆的临床效果及对患者血液流变学的影响  

Clinical effect of Cytidine Diphosphate Choline injection combined with memantine hydrochloride in the treatment of vascular dementia and its effect on Hemorheology

作　　者：巴一 高红安 岳晓棠 陈奥 宋程光 姜扬[2] 刘培慧[3] BA Yi;GAO Hong-An;YUE Xiao-Tang;CHEN Ao;SONG Cheng-Guang;JIANG Yang;LIU Pei-Hui(Department of Neurology,Liaoning Benxi Central Hospital,Benxi 117000,China;Department of Neurology,the first people's Hospital of Shenyang,Liaoning Province,Shenyang l10041,China;Department of Neurointervention,Huludao Central Hospital,LiaoningProvince,Huludao125000,China)

机构地区：[1]本溪市中心医院神经内科二病房,辽宁本溪117000 [2]辽宁省沈阳市第一人民医院神经内科,沈阳110041 [3]辽宁省葫芦岛市中心医院神经介入科,辽宁葫芦岛125000

出　　处：《中国药物经济学》2022年第10期102-105,共4页China Journal of Pharmaceutical Economics

基　　金：辽宁省科研博士启动资金(2019645);辽宁省自然科学基金(2019221)。

摘　　要：目的探讨胞二磷胆碱注射液联合盐酸美金刚治疗血管性痴呆的临床效果及对患者血液流变学的影响。方法选取2019年1月至2021年1月本溪市中心医院收治的血管性痴呆患者60例作为研究对象,按随机数字表法分为对照组与观察组,每组30例。对照组予以胞二磷胆碱注射液治疗,观察组采用胞二磷胆碱注射液联合盐酸美金刚治疗。比较两组患者治疗前后血液流变学指标、精神状态(简易精神状态评价量表(MMSE))与日常生活能力(ADL)评分,并评价治疗效果,统计不良反应发生情况。结果治疗后两组血液流变学指标较治疗前明显下降,且观察组明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组MMSE、ADL评分明显升高,且观察组明显高于对照组,差异有统计学意义(P<0.05)。观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在血管性痴呆患者治疗中,以胞二磷胆碱注射液联合盐酸美金刚治疗,可明显改善患者血液流变学指标,提升精神状态与日常生活能力,获得更佳的治疗效果。Objective To observe the clinical effect of Cytidine Diphosphate Choline injection combined with memantine hydrochloride in the treatment of vascular dementia and its effect on hemorheology.Methods 60 patients with vascular dementia admitted to Benxi Central Hospital from January 2019 to January 2021 were selected as the research objects,and were divided into control group and observation group according to random number table method,with 30 patients in each group.The control group was treated with Cytidine Diphosphate Choline injection,and the observation group was treated with Cytidine Diphosphate Choline injection and memantine hydrochloride.The hemorheology indexes,mental state(MMSE)and ability of daily living(ADL)scores of the two groups of patients before and after treatment were compared,and the treatment effect was evaluated,and the adverse reactions were counted.Results After treatment,the hemorheology indexes of the two groups decreased significantly compared with those before treatment,and the observation group was significantly lower than the control group,with a statistically significant difference(P<0.05).After treatment,the MMSE and ADL scores of the two groups were improved,and the scores of the observation group were significantly higher than those of the control group(P<0.05).The effective rate of treatment in the observation group was higher than that in the control group,with a statistically significant difference(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of patients with vascular dementia,Cytidine Diphosphate Choline injection combined with memantine hydrochloride can significantly improve the hemorheological indexes,improve the mental state and ability of daily living,and obtain a better therapeutic effect.

关 键 词：胞二磷胆碱注射液 盐酸美金刚 联合治疗 血管性痴呆 临床效果 血液流变学 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]