有机小分子催化不对称Michael加成反应研究进展  

Progress in asymmetric Michael addition reactions catalyzed by small organic molecules

作　　者：赵梅梅 高艳蓉 杜漠 唐文强 ZHAO Mei-mei;GAO Yan-rong;DU Mo;TANG Wen-qiang(Shaanxi Institute of International Trade&Commerce,Xi'an 712046,China;Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province,Xian 712046,China)

机构地区：[1]陕西国际商贸学院,陕西西安712046 [2]陕西省中药绿色制造技术协同创新中心,陕西西安712046

出　　处：《精细与专用化学品》2022年第12期24-27,33,共5页Fine and Specialty Chemicals

基　　金：陕西省教育厅2022年度专项科学研究计划(22JK0280);陕西国际商贸学院“中药药效物质研究”创新团队资助项目(SSY18TD02)。

摘　　要：Michael加成是一种高效形成碳-碳的有机反应,不对称Michael加成反应是合成具有手性中心化合物的重要方法。近年来,有机小分子催化剂促进的不对称Michael加成反应得到了快速的发展。按照种类的不同,有机小分子催化剂主要分为胺类有机小分子催化剂、吡咯烷类有机小分子催化剂、硫脲类有机小分子催化剂以及膦酸类有机催化剂等。综述了不对称Michael加成反应研究进展,期望对不对称催化反应研究起到参考和借鉴作用。Michael addition reaction is an efficient carbon-carbon bond formation reaction in organic chemistry.Asymmetric Michael addition is an important method to synthesize chiral compounds.In recent years,the research on asymmetric Michael addition reaction catalyzed by small organic molecules have been developed rapidly.According to the different types of small organic molecule catalysts,they were mainly divided into amine organic molecule catalysts,pyrrolidine organic molecule catalysts,thiourea organic molecule catalysts,phosphonic acid organic catalysts,etc.The research progress of asymmetric Michael addition reaction was reviewed,which was expected to be a reference for the study of asymmetric catalytic reaction.

关 键 词：小分子催化剂 不对称催化 MICHAEL加成反应 研究进展 

分 类 号：TQ426[化学工程]