胃癌术后胆囊结石形成的危险因素及预防措施的研究进展  

Research progress on the causes and prevention measures of cholecystolithiasis after gastric cancer surgery

作　　者：徐伟[1,2] 刘海鹏[2] 汪文杰 王舟 李元元 沈亦敏(综述) 陈晓(审校)[2] XU Wei;LIU Haipeng;WANG Wenjie;WANG Zhou;LI Yuanyuan;SHEN Yimin;CHEN Xiao(The Second Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of General Surgery,The Second Hospital of Lanzhou University)

机构地区：[1]兰州大学第二临床医学院普通外科,兰州730000 [2]兰州大学第二医院普通外科

出　　处：《实用肿瘤学杂志》2022年第6期561-565,共5页Practical Oncology Journal

基　　金：甘肃省自然科学基金(编号:21JR1RA126);甘肃省青年科技基金计划(编号:21JR7RA424)。

摘　　要：胃癌是常见的消化系统恶性肿瘤,治疗方式以手术为主。随着医疗水平的进步,胃癌患者的生存率有所提高,术后并发症也引起人们的关注,临床实践发现一些胃癌患者术后会发生胆囊结石或胆囊炎,有的甚至需二次手术治疗,严重影响了患者的生活质量。目前对于胃癌术后术后胆囊结石形成的危险因素尚无统一定论,较为明确的危险因素包括神经因素、胃切除范围、消化道激素、消化道重建及淋巴结清扫范围等。同样对于胃癌术后胆囊结石的预防尚无统一定论,其中是否需要进行预防性的胆囊切除仍存在很大的争议,也是临床医生关注的焦点。本文就胃癌术后胆囊结石形成的危险因素以及目前最新的预防措施做一综述,希望能对临床工作有所帮助。Gastric cancer(GC)is a common malignant tumor of the digestive system, which is mainly treated by surgery.With the improvement of medical level, the survival rate of gastric cancer patients has improved compared with the past.Postoperative complications have also attracted people′s attention.Clinical practice has found that some patients with GC may develop cholecystolithiasis or cholecystitis after surgery, and some even require secondary surgery, which seriously affects the quality of patients′ life.At present, there is no unified consensus on the risk factors of cholecystolithiasis after GC surgery.The relatively clear factors include neural factors, the scope of gastrectomy, gastrointestinal hormones, gastrointestinal reconstruction and lymph node dissection.At present, there is no consensus on the prevention of cholecystolithiasis after GC surgery, especially whether preventive cholecystectomy is needed, which is also the focus of clinicians.This article reviews the risk factors of cholecystolithiasis after GC surgery and the latest preventive measures, hoping to help clinical work.

关 键 词：胃癌术后 胆囊结石 危险因素 熊去氧胆酸 

分 类 号：R735.2[医药卫生—肿瘤]