脾脏体积变化及血清炎性因子对急性脑梗死严重程度的预测价值  

The spleen volume and serum inflammatory factors in predicting the severity of acute ischemic stroke

作　　者：汪步玲 张骏 关闪闪 郭云云 王训[1] WANG Buling;ZHANG Jun;GUAN Shanshan(Second Affiliated Hospital of Anhui Medical University,Hefei 230601,China)

机构地区：[1]安徽医科大学第二附属医院,安徽合肥230601

出　　处：《中风与神经疾病杂志》2022年第12期1060-1064,共5页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金(2020GQFY02)。

摘　　要：目的探究脾脏体积变化及血清炎性因子对急性脑梗死(AIS)严重程度的预测价值。方法选取我院2022年1月-2022年6月发病24 h内的AIS患者62例作为研究对象,根据美国国立卫生院神经功能缺损(NIHSS)评分,分为轻度组(NIHSS<6分,n=30)及中重度组(NIHSS≥6分,n=32)。比较两组患者血清炎性因子及发病24 h内脾脏体积与发病48 h脾脏体积标准化差值的差异。ROC曲线分析血清炎性因子及脾脏体积标准化差值对AIS严重程度预测价值。结果两组患者在IL-5、IL-6、IL-1β、IL-8、IL-17、IL-12P70、TNF-α及脾脏体积标准化差值差异均有统计学意义(P<0.05)。IL-6、IL-12P70及脾脏体积标准化差值评估AIS严重程度ROC曲线下面积(AUC)分别为0.715、0.715、0.826,其中脾脏体积标准化差值预测AUC最大,预测敏感度及特异度分别为90.0%、74.1%。结论脾脏体积标准化差值及血清炎性因子与AIS严重程度相关,且可作为预测AIS严重程度的指标。Objective Study on the spleen volume and serum inflammatory factors in predicting the severity of acute ischemic stroke.Methods A total of 62 patients with AIS within 24 hours of onset,admitted to our hospital from January 2021 to June 2022,were selected as the study subjects.According to the National Institutes of Health Stroke Scale(NIHSS),they were divided into mild group(NIHSS<6 points,n=30)and moderate as well as severe group(NIHSS≥6 points,n=32).The differences in serum inflammatory factors and normalized difference in spleen volume between the two groups were compared.ROC curve was used to analyze value of serum inflammatory factors and normalized difference in spleen volume in evaluating the severity of AIS.Results There were statistically significant differences in IL-5,IL-6,IL-1β,IL-8,IL-17,IL-12P70,TNF-αand normalized difference in spleen volume between two groups(P<0.05).The area under ROC curve(AUC)of IL-6,IL-12P70 and normalized difference in spleen volume for assessing AIS severity were 0.715,0.715 and 0.826,respectively.Normalized difference in spleen volume had the largest AUC prediction,and the sensitivity and specificity were 90.0%and 74.1%.Conclusion Normalized difference in spleen volume and serum inflammatory factors are correlated with the severity of AIS,and can be used as indicators to predict the severity of AIS.

关 键 词：脾脏体积 血清炎性因子 急性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]