尿酸氧化酶固定化应用于高尿酸血症研究进展  

Research progress on immobilization of urate oxidase and its application in hyperuricemia

作　　者：汪志伟 任梦飞 夏觅真 吴琳梅 WANG Zhiwei;REN Mengfei;XIA Mizhen;WU Linmei(School of Life Sciences,Anhui Medical University,Hefei 230032,China)

机构地区：[1]安徽医科大学生命科学学院,安徽合肥230032

出　　处：《高师理科学刊》2022年第11期63-66,共4页Journal of Science of Teachers＇College and University

基　　金：安徽医科大学博士科研基金项目(XJ201515);安徽医科大学2021年大学生创新创业训练计划项目(202110366046X)。

摘　　要：高尿酸血症是严重影响身体健康和生活质量的一大疾病.尿酸氧化酶(UOX)能够催化尿酸生成水溶性尿素囊,从而降低尿酸水平,起到治疗高尿酸血症的作用.但是,UOX作为一种外源性蛋白质,存在体内稳定性低、半衰期短、抗原性强、治疗价格高等问题,限制了其在临床上的使用.通过酶的固定化技术,可以克服UOX的缺点,扩大其在治疗高尿酸血症上的应用.对UOX的固定化及其应用于高尿酸血症的相关研究进行综述,旨在为UOX类药物开发提供参考.Hyperuricemia is a major disease that seriously affects health and quality of life.Urate oxidase(UOX)can treat hyperuricemia because that it can catalyze enzymatic oxidation of uric acid to allantoin,which reduce the level of plasma uric acid.However,as an exogenous protein,UOX has the problems,such as low in vivo stability,short half-life,strong antigenicity and high treatment price,which limit its clinical use.Through the enzyme immobilization technology,the shortcomings of UOX can be overcome and its application in the treatment of hyperuricemia can be expanded.The immobilization of UOX and the related researches on its application in hyperuricemia were reviewed in order to provide reference for the development of UOX drugs.

关 键 词：高尿酸血症 尿酸氧化酶 固定化酶 载体材料 

分 类 号：Q814[生物学—生物工程]