Clinical efficacy of 0.05%cyclosporine nano-emulsion in the treatment of dry eye syndrome associated with meibomian gland dysfunction  

作　　者：Yeon Ji Jo Ji Eun Lee Jong Soo Lee 

机构地区：[1]Efficacy of nano-cyclosporine to DES with MGD 1 Department of Ophthalmology,Pusan National University School of Medicine&Medical Research Institute,Pusan National University Hospital,Pusan 49241,Republic of Korea [2]Department of Ophthalmology,Pusan National University School of Medicine&Medical Research Center,Yangsan Pusan National University Hospital,Yangsan 626-770,Republic of Korea

出　　处：《International Journal of Ophthalmology(English edition)》2022年第12期1924-1931,共8页国际眼科杂志（英文版）

基　　金：Supported by Biomedical Research Institute Grant(No.20200026),Pusan National University Hospital。

摘　　要：AIM:To evaluate the clinical efficacy of topical 0.05%cyclosporine nano-emulsion in the treatment of dry eye syndrome(DES)with meibomian gland dysfunction(MGD).METHODS:This prospective study included 64 patients with DES and MGD who were randomly assigned to three groups:Group 1(n=24,conventional cyclosporine),Group 2(n=21,nano-emulsion cyclosporine),and Group 3(n=19,control).Lid margin telangiectasia(LMT),meibomian gland secretion(MGS),conjunctival injection(CI),corneal staining(CS),tear break-up time(TBUT),Schirmer test I(STI),Ocular Surface Disease Index(OSDI),and lipid layer thickness(LLT)was evaluated at 4,8,and 12wk of treatment.RESULTS:In Group 3(control),LMT,CS,and CI improved after 8wk,MGS,TBUT after 12wk of treatment.In Group 1(conventional cyclosporine),LMT,MGS,and TBUT improved significantly after 4wk,whereas CS,CI,STI,and LLT improved significantly after 8wk,and OSDI at 12wk.In Group 2(nano-cyclosporine),LMT,MGS,CS,CI,TBUT,and OSDI significantly improved after 4wk,and STI after 8wk.Especially,LLT was significantly higher than other groups after 4wk.CONCLUSION:Cyclosporine and nano-cyclosporine shows significant improvement in DES with MGD than the control group.In contrast,the nano-cyclosporine group shows more statistically improved CI and CS at 4wk,especially LLT at 4,8,and 12wk compared to the conventional cyclosporine group.

关 键 词：anti-inflammatory treatment CYCLOSPORINE dry eye disease meibomian gland dysfunction 

分 类 号：R777.34[医药卫生—眼科] R777.13[医药卫生—临床医学]