周细胞的研究现状及其在妇产科中的研究展望  

Research progress ofpericytes and its prospectingynaecologyand obstetrics

作　　者：刘钊 韩宝生[2] 张景华 张秀军 Liu Zhao;Han Baosheng;Zhang Jinghua;Zhang Xiujun(College of Public Health,North China University of Science and Technology,Tangshan 063210,China;Department of Reproductive Genetics,Tangshan Maternal and Children Health Hospital,Tangshan 063000,China)

机构地区：[1]华北理工大学公共卫生学院,唐山063210 [2]唐山市妇幼保健院生殖遗传科,唐山063000

出　　处：《中华生殖与避孕杂志》2022年第11期1192-1198,共7页Chinese Journal of Reproduction and Contraception

摘　　要：周细胞是围绕在毛细血管内皮细胞外的血管壁细胞。周细胞可以在多种疾病中通过调节血管形态及功能发挥重要作用,如糖尿病视网膜病变、阿尔茨海默症、出血性脑卒中、组织纤维化、肿瘤转移等。此外,周细胞还是间充质祖细胞,可以分化产生(肌)成纤维细胞、血管平滑肌细胞、脂肪细胞、软骨、骨骼和肌肉等。本文将对周细胞的研究现状进行综述,并对子宫中周细胞未来可能的研究方向进行展望。Pericytes are microvascular mural cells surrounding the endothelial cells of capillaries.Pericytes play a critical role in various diseases by regulating vascular morphology and function,such as diabetic retinopathy,Alzheimer's disease,hemorrhagic stroke,tissue fibrosis and tumor metastasis.Moreover,pericytes are mesenchymal progenitor cells that can differentiate into fibroblasts,vascular smooth muscle cells,adipose cells,cartilage,bone,and muscle.There are few studies on pericytes during pregnancy,and some existing evidence points to pericytes playing an essential role in some aspects of pregnancy.In this paper,the research progress of pericytes was reviewed,and the future research direction of uterine pericytes was prospected.

关 键 词：周细胞 妊娠 生殖 血管渗透性 胚胎植入 蜕膜化 子宫 

分 类 号：R71[医药卫生—妇产科学]