全身PET/CT动态显像评估胰腺癌患者^(68)Ga-FAPI-04的动力学参数  

Kinetic metrics of^(68)Ga-FAPI-04 in patients with pancreatic cancer identified by total-body PET/CT dynamic imaging

作　　者：陈若华 杨昕岚 霍砚淼[3] 王一宁 俞小凤[1] Yee Ling Ng 郑超杰 赵海涛 李梁华 Yun Zhou 黄钢[1] 刘建军[1] Chen Ruohua;Yang Xinlan;Huo Yanmiao;Wang Yining;Yu Xiaofeng;Yee Ling Ng;Zheng Chaojie;Zhao Haitao;Li Lianghua;Yun Zhou;Huang Gang;Liu Jianjun(Department of Nuclear Medicine,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China;Central Research Institute,United Imaging Healthcare Group Co.,Ltd,Shanghai 201807,China;Department of Biliary-Pancreatic Surgery,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院核医学科,上海200127 [2]上海联影医疗科技股份有限公司中央研究院,上海201807 [3]上海交通大学医学院附属仁济医院胆胰外科,上海200127

出　　处：《中华核医学与分子影像杂志》2022年第12期729-733,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家重点研发计划(2021YFA0910004);国家自然科学基金(82177807,81830052,82171972);上海市卫生健康委员会卫生行业临床研究专项(20214Y0438);上海市"医苑新星"青年医学人才培养资助计划(SHWRS(2021)_099)。

摘　　要：目的应用全身PET/CT动态显像评估胰腺癌患者中病变和正常器官^(68)Ga-成纤维细胞激活蛋白抑制剂(FAPI)-04的动力学参数。方法回顾性分析2020年12月至2021年12月在上海交通大学医学院附属仁济医院行^(68)Ga-FAPI-04全身PET/CT动态显像的胰腺癌患者(6例,男女各3例,中位年龄55.5岁)影像资料,勾画部分正常器官和病变(原发肿瘤、淋巴结转移和腹膜转移)的感兴趣体积,生成时间-活度曲线(TACs)。正常器官和病灶的TAC均采用二组织房室可逆模型(2TCM)进行拟合,获得包括K_(1)、k_(2)、k_(3)和k4在内的速率常数及总分布容积(V_(t)),并按组织类型进行比较。采用Wilcoxon秩和检验和Spearman秩相关分析数据。结果正常器官和胰腺癌病变的动力学参数存在明显差异(z值:2.00~1240.00,均P<0.05)。病变中原发肿瘤的K_(1)最高(0.30 min^(-1)),正常器官中脾的K_(1)最高(1.42 min^(-1));病变中腹膜转移的k_(2)最高(0.24 min^(-1)),正常器官中脾的k_(2)最高(2.59 min^(-1));病变中原发肿瘤的k_(3)最高(0.17 min^(-1)),正常器官中胰腺的k_(3)最高(0.16 min^(-1));病变中原发肿瘤的k4最高(0.03 min^(-1)),正常器官中心脏、肺、腮腺的k4较高(0.06 min^(-1))。与正常器官相比,病变中的V_(t)明显提高,其中原发肿瘤的V_(t)最高,为13.78 ml/cm^(3)。病变V_(t)与SUVmean、SUVmax均相关(r_(s)值:0.86和0.77,均P<0.001)。结论^(68)Ga-FAPI-04的速率常数K_(1)、k_(2)、k_(3)和k4及V_(t)在部分正常器官和病变中明显不同。Objective To investigate the kinetic metrics of^(68)Ga-fibroblast activation protein inhibitor(FAPI)-04 in pancreatic cancer_(s)and normal organs by using total-body PET dynamic imaging.Methods From December 2020 to December 2021,^(68)Ga-FAPI-04 total-body PET/CT dynamic imaging were performed on 6 pancreatic cancer patients(3 males,3 females,median age 55.5 year_(s))in Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong Univer_(s)ity.Images were respectively analyzed.Manual delineations of volume of interests(VOIs)on multiple normal organs and pathological lesions were performed and time-to-activity curves(TACs)were generated.A rever_(s)ible two-tissue compartment model(2TCM)was fitted for each tissue TAC.Rate constants including K_(1),k_(2),k_(3)and k4,and the total volume of distribution(V_(t))were obtained and compared by tissue types.Wilcoxon rank sum test and Spearman correlation analysis were used for data analysis.Results Kinetic metrics varied significantly among normal organs and pancreatic cancer lesions(z values:2.00-1240.00,all P<0.05).The highest K_(1)among lesions was observed in primary tumor(0.30 min^(-1)),which was observed in the spleen(1.42 min^(-1))among normal organs.The highest k_(2)among lesions was observed in peritoneal metastases(0.24 min^(-1)),which was observed in the spleen(2.59 min^(-1))among normal organs.Primary tumor showed the highest k_(3)of 0.17 min^(-1)among lesions,and the pancreas had the highest k_(3)of 0.16 min^(-1)among normal organs.Primary tumor had the highest k4 of 0.03 min^(-1)among lesions,and the heart,lungs,parotid glands had high k4(0.06 min^(-1))among normal organs.V_(t)were higher in pathological lesions compared to normal organs,with the highest in primary tumor(13.78 ml/cm^(3)).There were correlations between V_(t)in lesions and SUVmean(r_(s)=0.86,P<0.001)or SUVmax(r_(s)=0.77,P<0.001).Conclusion The rate constants including K_(1),k_(2),k_(3)and k4,and V_(t)of^(68)Ga-FAPI-04 vary among normal organs and lesions.

关 键 词：动态显像 成纤维细胞激活蛋白 正常器官 胰腺癌患者 分布容积 仁济医院 原发肿瘤 腹膜转移 

分 类 号：R735.9[医药卫生—肿瘤] R730.44[医药卫生—临床医学]