高原藏族移居平原初期身体素质与肝功能变化的关系研究  

Study on the Relationship between Physical Fitness and Liver Function Changes in the Early Stage of High Altitude Tibetans Migration to Plain

作　　者：陈婷[1] 王叶秋 申艳 杨伟[2] 赵昕 CHEN Ting;WANG Yeqiu;SHEN Yan;YANG Wei;ZHAO Xin(High altitude Sports and Health Research Center/Key Laboratory of High Altitude Hypoxic Environment and Life Health,Xizang Minzu University Xianyang,Shanxi 71208,China;Affiliated Hospital of Xizang Minzu University,Xianyang 712082,China;Xianyang Central Hospital,Xianyang 712000,China)

机构地区：[1]西藏民族大学高原体育与健康研究中心/高原低氧环境与生命健康重点实验室,陕西咸阳712082 [2]西藏民族大学附属医院,陕西咸阳712082 [3]咸阳市中心医院,陕西咸阳712000

出　　处：《高原科学研究》2022年第4期50-57,共8页Plateau Science Research

基　　金：国家自然科学基金项目(82060422);西藏自治区教育厅重大委托课题子项目:西藏高原体育人口适宜运动研究;西藏民族大学高原低氧环境与生命健康实验室开放课题(XZMU-2022M-H03)。

摘　　要：目的:探讨不同身体素质的世居高原藏族青年,移居平原初期肝脏功能变化规律。方法:选取从高原(西藏)初入平原(陕西)的藏族青年3044名(男1476名,女1568名)为研究对象,进行脱适应症状筛查。根据身体素质测试结果,将受试者分为3组:身体素质>75分组、60~75分组、<60分组。分别于初入平原3、6、9天检测肝脏功能指标。采用卡方检验比较各组间肝功能指标超标率,二元Logistic回归分析探讨身体素质与肝功能指标异常的关系。结果:脱适应3天时,60分以下组肝脏指标水平(男,丙氨酸氨基转移酶)显著高于60~75分组;γ-谷氨酰转肽酶、直接胆红素、总胆汁酸、总胆红素(男)显著高于75分以上组(P<0.01);间接胆红素(男)显著高于其余两组(P<0.01)。脱适应6天时,总胆汁酸(女)60分以下组显著高于其余两组。脱适应9天时,60分以下组丙氨酸氨基转移酶、天门冬氨酸氨基转移酶(女),γ-谷氨酰转肽酶(男)显著高于60~75分组;γ-谷氨酰转肽酶(女)显著高于其余两组;血清总蛋白(女)显著低于60~75分组;(男、女,白蛋白)显著低于75分以上组(除标记外,均P<0.05)。且身体素质低于60分组肝脏指标超标率(男,丙氨酸氨基转移酶、γ-谷氨酰转肽酶;男、女,总胆汁酸)显著高于其他两组(χ^(2)分别为18.06,10.76,15.97,22.04,均P<0.01),天门冬氨酸氨基转移酶(男)超标率显著高于60~75分组(χ^(2)为7.47,P<0.05)。身体素质在60分以下是丙氨酸氨基转移酶(OR=1.67,95%CI为1.24~2.26)、γ-谷氨酰转肽酶(OR=2.31,95%CI为1.25~4.25)异常的危险因素。结论:世居高原藏族移居平原初期,肝脏转运与代谢指标整体异常率较高。身体素质在60分以下的藏族,初入平原肝脏损伤、转运与代谢指标恢复较慢,且异常率较高。身体素质低于60分为高原藏族初入平原肝脏损伤指标异常的危险因素。ObjectiveTo explore the changes of liver function in Tibetan youth living in high altitudes with different physical fitness during the early period of their migration to the plains.MethodsA total of 3044 Tibetan youth(1476 males and 1568 females)who first descend to the plain(Shanxi)from the high altitude(Tibet)were selected as the research subjects,and were screened for symptoms of de-adaptation.According to the results of physical fitness test,the subjects were divided into three groups:physical fitness>75 group,60~75 group,<60group.The liver function indexes were detected on 3rd,6th,and 9th days after first descend to the plain.The Chi-square test was used to detect the excess rate of liver function indicators among each group,and binary Logistic regression analysis was used to explore the relationship between physical fitness and abnormal liver function indicators.ResultsOn the 3rd day of de-adaptation,the liver index level(male ALT)in the<60 group was significantly higher than 60~75 group;GGT,DBIL,TBA,TBIL(male)were significantly higher than>75 group(P<0.01).At the 6th day of de-adaptation,<60 group with TBA(female)was significantly higher than the other two groups.On the 9th day of de-adaptation,ALT,AST(female)and GGT(male)in<60 group were significantly higher than 60~75 group;GGT(female)was significantly higher than the other two groups;TP(female)was significantly lower than that of the 60~75 group;(Male and female ALB)were significantly lower than>75 group(except for the markers,all P<0.05).The over standard rate of liver indicators(male ALT,GGT,male and female TBA)in<60 group was significantly higher than that in the other two groups(χ^(2)=18.06,10.76,15.97,22.04,all P<0.01).The rate of AST(male)exceeding the standard was significantly higher than 60-75 group(χ^(2)=7.47,P<0.05).Physical fitness below 60 is a risk factor for abnormal ALT(OR=1.67,95%CI=1.24~2.26)and GGT(OR=2.31,95%CI=1.25~4.25).ConclusionIn the early stage of migrating to the plain among Tibetans who living in the high altitude,the overa

关 键 词：移居平原 身体素质 高原藏族 脱适应 肝脏功能 

分 类 号：R575[医药卫生—消化系统]