中性粒细胞与淋巴细胞比值联合ABCD2评分预测短暂性脑缺血发作早期脑梗死的价值分析  

Analysis of Predictive Value of Neutrophil to Lymphocyte Ratio Combined with ABCD2 Score for Early Cerebral Infarction after Transient Ischemic Attack

作　　者：王伟[1,2] 宫秀群 Wang Wei;Gong Xiu-qun(Department of Neurology,Yancheng First Hospital,Affiliated Hospital of Nanjing University Medical School(Yancheng No1.People's Hospital),Yancheng 224001,Jiangsu Province,China;Yancheng Psychiatric and Psychological Disorders Clinical and Transformation Institute,Yancheng 224001,Jiangsu Province,China;Department of Neurology,Affiliated Hospital of Anhui University of Science and Technology,Huainan 232001,Anhui Province,China)

机构地区：[1]南京大学医学院附属盐城第一医院(盐城市第一人民医院)神经内科,江苏盐城224001 [2]盐城市精神心理疾病临床与转化研究所,江苏盐城224001 [3]安徽理工大学附属医院神经内科,安徽淮南232001

出　　处：《中国社区医师》2022年第36期89-92,共4页Chinese Community Doctors

基　　金：安徽省教育厅重点项目(KJ2021A0434)。

摘　　要：目的:探讨中性粒细胞与淋巴细胞比值(NLR)联合ABCD2评分对短暂性脑缺血发作(TIA)7 d内发生脑梗死的预测价值。方法:回顾性分析2018年10月-2019年9月淮南市第一人民医院神经内科收治的132例TIA患者的临床资料,根据发病后7 d内是否发生脑梗死分为卒中组和非卒中组。比较两组患者的人口学资料和临床基线资料特征,应用Logistic回归分析确定TIA后早期发生脑梗死的独立危险因素,应用ROC曲线评价NLR联合ABCD2评分对TIA早期发生脑梗死的预测价值。结果:132例患者中,在TIA后7 d内发生脑梗死18例,占比13.6%。单因素分析显示,两组中性粒细胞计数、淋巴细胞计数、糖尿病、ABCD2评分≥4分、NLR是脑梗死发生的影响因素,差异有统计学意义(P<0.05)。Logistic回归分析显示,高NLR、ABCD2≥4分、糖尿病是TIA早期脑梗死发生的独立危险因素。ROC分析结果显示,NLR预测TIA后脑梗死风险的AUC为0.745,ABCD2评分预测TIA后脑梗死风险的AUC为0.665,NLR联合ABCD2评分预测TIA后脑梗死风险的AUC为0.790。结论:NLR联合ABCD2评分是预测TIA后短期发生脑梗死的简单、有效的工具,将NLR和ABCD2评分联合能提高对脑梗死的预测价值。Objective: To investigate the predictive value of neutrophil to lymphocyte ratio(NLR) combined with ABCD2 score on the occurrence of cerebral infarction within 7 days of transient ischemic attack(TIA). Methods: The clinical fata of 132 TIA patients admitted to the Department of Neurology, Huainan First People’s Hospital from October 2018 to September 2019 were retrospectively analyzed. According to whether cerebral infarction occurred within 7 days after the onset of the disease, they were divided into stroke group and non-stroke group. The demographic data and clinical baseline data characteristics of the two groups were compared;Logistic regression analysis was applied to determine the independent risk factors for early onset of cerebral infarction after TIA, and ROC curve was applied to evaluate the predictive value of NLR combined with ABCD2 score for early onset of cerebral infarction after TIA. Results: Among 132 patients, 18 patients(13.6%) had cerebral infarction within 7 days after TIA. Univariate analysis showed that the neutrophil count, lymphocyte count, diabetes mellitus, ABCD2 score ≥ 4 points, and NLR are the influencing factors for the occurrence of cerebral infarction, with statistically significant differences(P<0.05). Logistic regression analysis showed that, high NLR, ABCD2 score ≥ 4 points, and diabetes were the independent risk factors for early cerebral infarction after TIA. ROC analysis results showed that, the AUC for NLR predicting the risk of cerebral infarction after TIA was 0.745, the AUC for ABCD2 score predicting the risk of cerebral infarction after TIA was 0.665, and the AUC for NLR combined with ABCD2 score predicting the risk of cerebral infarction after TIA was 0.790. Conclusion: NLR combined with ABCD2 score is a simple and effective tool to predict the occurrence of cerebral infarction within a short term after TIA. The combination of NLR and ABCD2 score can improve the predictive value of cerebral infarction.

关 键 词：短暂性脑缺血发作 脑梗死 ABCD2评分 中性粒细胞 淋巴细胞 

分 类 号：R743.3[医药卫生—神经病学与精神病学]