线粒体功能障碍在化疗所致周围神经病变中的作用机制研究进展  

Mechanism of mitochondrial dysfunction in chemotherapy‑induced peripheral neuropathy

作　　者：王媛 王艳[2] 马铭 裴飞[2] Wang Yuan;Wang Yan;Ma Ming;Pei Fei(Heilongjiang University of Chinese Medicine Second Clinical School,Harbin 150040,China;Department of Rehabilitation,Second Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学第二临床医学院,哈尔滨150040 [2]黑龙江中医药大学附属第二医院康复科,哈尔滨150001

出　　处：《药物不良反应杂志》2022年第12期658-663,共6页Adverse Drug Reactions Journal

基　　金：国家自然科学基金(81973926);黑龙江省自然科学基金(LH2021H090);黑龙江中医药大学"优秀创新人才支持计划"科研项目(2018RCD09)。

摘　　要：化疗所致周围神经病变(CIPN)通常表现为持续的疼痛及感觉异常,严重时可能出现振动感和关节位置感丧失、自主神经和运动功能障碍,严重影响患者的生活质量。线粒体功能障碍可能是化疗药物诱发周围神经病变的机制之一。本文从5个方面综述了不同化疗药物导致的不同的线粒体功能障碍,包括如神经元线粒体形态异常、线粒体通透性转换孔激活及其相关钙失衡、线粒体生物能量学功能失调、氧化应激及轴突线粒体转运异常等。避免或改善线粒体功能障碍是预防或减轻CIPN的主要策略。Chemotherapy-induced peripheral neuropathy(CIPN)usually manifests as persistent pain and sensory abnormalities,and in severe cases,loss of vibration and joint position sensation,autonomic and motor dysfunction may occur,severely affecting patients′quality of life.Mitochondrial dysfunction may be one of the mechanisms by which chemotherapeutic drugs induce peripheral neuropathy.Different mitochondrial dysfunction caused by different chemotherapy agents are reviewed from 5 aspects in this paper,including abnormal neuronal mitochondrial morphology,activation of mitochondrial permeability transition pore and its associated calcium imbalance,dysfunction of mitochondrial bioenergetics,oxidative stress,and abnormal axonal mitochondrial transport.Avoiding or improving mitochondrial dysfunction is the main strategy to prevent or mitigate CIPN.

关 键 词：周围神经系统疾病 神经病理性疼痛 线粒体肿胀 氧化应激 线粒体功能障碍 化学疗法 

分 类 号：R745[医药卫生—神经病学与精神病学]