咬合创伤在牙周炎发生发展中的作用及机制的研究进展  

Research progress on the role and mechanism of occlusal trauma in the development of periodontitis

作　　者：刘体倩 梁星[1] 刘蔚晴 李晓虹 朱睿 Liu Tiqian;Liang Xing;Liu Weiqing;Li Xiaohong;Zhu Rui(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Prosthodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院修复科,成都610041

出　　处：《国际口腔医学杂志》2023年第1期19-24,共6页International Journal of Stomatology

摘　　要：牙周炎是成人失牙的首要原因,严重影响患者的身心健康。研究表明,单纯的咬合创伤不会导致牙周炎,但在炎症状态下咬合创伤能够促进牙周炎的发生发展,因此咬合创伤是牙周炎的危险因素之一。本文就咬合创伤在牙周炎发生发展中的炎症促进、成骨抑制和破骨激活三方面的作用及其相关分子机制作一综述。Periodontitis is the most common reason for adult tooth loss, which negatively impacts the physical and mental health of patients. Recent studies have shown that occlusal trauma might be a risk factor for periodontitis: although occlusal force did not initiate periodontal disease, it could aggravate periodontitis. Therefore, this paper reviews the role of occlusal trauma in promoting inflammation, inhibiting osteogenesis, stimulating osteoclastogenesis, and related molecular mechanisms during the onset and progression of periodontitis.

关 键 词：牙周炎 咬合创伤 炎症 成骨分化 破骨激活 

分 类 号：R781.45[医药卫生—口腔医学]