解郁复胃散联合莫沙必利治疗功能性消化不良效果及对胃肠动力、血清obestatin、NPSR1表达的影响  

Curative Effect of Jieyu Fuwei Powder(解郁复胃散)Combined with Mosapride on Functional Dyspepsia and Its Influences on Gastrointestinal Motility,Serum Obestatin and NPSR1

作　　者：程峰 李万红 陈峰生 钱梅 季瑜 CHENG Feng;LI Wanhong;CHEN Fengsheng;QIAN Mei;JI Yu(Haian Hospital of Traditional Chinese Medicine,Haian 226600,Jiangsu,China)

机构地区：[1]海安市中医医院,江苏海安226600

出　　处：《辽宁中医杂志》2022年第12期84-87,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：南通市基础研究和民生科技计划指导性项目(MSZ21060)。

摘　　要：目的 探讨解郁复胃散联合莫沙必利治疗功能性消化不良(FD)的效果及对胃肠动力、血清肥胖抑制素(obestatin)、神经肽S受体1(NPSR1)表达的影响。方法 选取2019年10月—2021年10月在海安市中医医院确诊的130例FD患者,随机将其分为观察组和对照组,每组65例。对照组采用莫沙必利治疗,观察组采用解郁复胃散联合莫沙必利治疗,均持续治疗4周。4周后评估两组患者的临床疗效,比较两组患者治疗前后的中医证候积分,采用红外光谱测定仪检测胃排空率,采用钡餐标记法检测胃排空时间,采用酚红定量测定法检测小肠推进率,采用酶联免疫吸附法检测血清obestatin和NPSR1水平,比较两组患者治疗期间不良反应发生率。结果 观察组治疗的有效率为89.23%(58/65),高于对照组的75.38%(49/65)(P<0.05)。治疗后,观察组主症积分低于对照组(P<0.05),观察组胃排空率和小肠推进率高于对照组,胃排空时间短于对照组(P<0.05),观察组obestatin表达水平低于对照组,NPSR1表达水平高于对照组(P<0.05),观察组患者治疗期间总不良反应发生率为12.31%(8/65),与对照组的9.23%(6/65)差异无统计学意义(P>0.05)。结论 解郁复胃散联合莫沙必利治疗可以明显提高FD患者的临床疗效,还可调节胃肠动力,降低血清obestatin表达水平,提高NPSR1表达水平。Objective To explore the curative effect of Jieyu Fuwei Powder(解郁复胃散)combined with mosapride on functional dyspepsia(FD)and its influences on gastrointestinal motility,levels of serum obestatin and neuropeptide S receptor 1(NPSR1).Methods A total of 130 patients with FD confirmed in the hospital were enrolled between October 2019 and October 2021.They were randomly divided into observation group and control group,65 cases in each group.The control group was treated with mosapride.The patients in observation group were treated with Jieyu Fuwei Powder and mosapride.After 4 weeks of treatment,the clinical curative effect in both groups was evaluated.The scores of TCM syndromes between the two groups were compared before and after treatment.The gastric emptying rate was detected by infrared spectrometer.The gastric emptying time was detected by barium meal labeling method.The intestinal propulsive rate was detected by phenol red quantitative assay.The levels of serum obestatin and NPSR1 were detected by enzyme-linked immunosorbent assay.The incidence of adverse reactions during treatment was compared between the two groups.Results The effective rate in the observation group was higher than that in the control group[89.23%(58/65)vs 75.38%(49/65)](P<0.05).After treatment,the scores of main symptoms in the observation group were lower than those in the control group(P<0.05).The gastric emptying rate and intestinal propulsive rate in the observation group were higher than those in the control group and the gastric emptying time was shorter than that in the control group(P<0.05).The expression level of obestatin was lower than that in the control group,and the expression level of NPSR1 was higher than that in the control group(P<0.05).The difference in the total incidence of adverse reactions during treatment between observation group and control group was not statistically significant[12.31%(8/65)vs 9.23%(6/65)](P>0.05).Conclusion Jieyu Fuwei Powder combined with mosapride can significantly improve the clinical

关 键 词：解郁复胃散 莫沙必利 功能性消化不良 胃肠动力 肥胖抑制素 神经肽S受体1 

分 类 号：R57[医药卫生—消化系统]