黄斑色素光学密度与黄斑区视网膜厚度及眼轴长度的相关性研究  

Research on correlation between MPOD with retinal thickness in macular region and ocular axis

作　　者：张静 陈再洪[2] 刘珏[2] ZHANG Jing;CHEN Zaihong;LIU Jue(Health Management Center,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China;Department of Ophthalmology,Chongqing Municipal Emergency Medical Center,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属第二医院健康管理中心,400010 [2]重庆市急救医疗中心眼科,400014

出　　处：《重庆医学》2023年第1期34-38,共5页Chongqing medicine

基　　金：重庆市卫生健康委医学科研项目(2022WSJK078)。

摘　　要：目的探讨黄斑色素光学密度(MPOD)与黄斑区视网膜厚度及眼轴长度的相关性。方法回顾性收集2018年7-12月在重庆市急救医疗中心眼科近视眼门诊就诊的18~30岁的96例(191眼)近视患者的相关资料,根据眼轴长度分为正常眼轴组(22~<24 mm)67眼,中长眼轴组(24~<26 mm)69眼,长眼轴组(≥26 mm)55眼,比较各组黄斑区视网膜厚度、MPOD,分析其相关性。结果各组年龄分布差异无统计学意义(P>0.05),性别、黄斑区平均色素光密度(Mean MPOD)及黄斑区最大色素光密度(Max MPOD)差异有统计学意义(P<0.05)。各组内环区、中心区、外环区视网膜厚度有差异(P<0.05),平均视网膜厚度比较差异无统计学意义(P>0.05)。相关性分析发现Mean MPOD与眼轴长度呈负相关(r=-0.525,P<0.001),眼轴长度与中心区视网膜厚度呈正相关(r=0.196,P=0.006),眼轴长度与外环区视网膜厚度呈负相关(r=-0.256,P<0.001);Mean MPOD与外环区视网膜厚度呈正相关(r=0.168,P=0.020),与中心区、内环区视网膜厚度、平均视网膜厚度无明显相关性(P>0.05)。结论Mean MPOD的减少与外环区视网膜厚度变薄呈线性正相关,与内环区及中心区视网膜厚度变化无线性相关性。Objective To investigate the correlation between the macular pigment optical density(MPOD)with retinal thickness in macular region and ocular axis.Methods The related data of 96 outpatients(191 eyes)aged 18-30 years old in the ophthalmology myopia clinic of Chongqing Municipal Emergency Medical Center were retrospectively collected.The patients were divided into the normal ocular axis group(22-<24 mm,67 eyes),mid-long ocular axis group(24-<26 mm,69 eyes)and long ocular axis group(≥26 mm,55 eyes)according to the ocular axis length.The retinal thickness and MPOD were compared among the groups and their correlation was analyzed.Results The age distribution had no statistical difference among the groups(P>0.05).The mean MPOD and maximal MPOD in the macular region had statistical difference(P<0.05).There was statistical difference in retinal thickness in the center,inner and outer ring area among all groups(P<0.05).The average retinal thickness had no statistical difference(P>0.05).The correlation analysis found that the mean MPOD value was negatively correlated with the ocular axis(r=-0.525,P<0.001),the ocular axis length was positively correlated with retinal thickness in the central area(r=0.196,P=0.006),the ocular axial length was negatively correlated with retinal thickness in the outer ring region(r=-0.256,P<0.001);while the mean MPOD value was positively correlated with the retin al length in the outer ring region(r=0.168,P=0.020)and had no obvious correlation with the central region,retinal thickness in the inner ring region and average retinal thickness(P>0.05).Conclusion The decrease of mean MPOD value has linear positive correlation with the thinning of retinal thickness in the outer ring region and has no linear correlation with the changes of retinal thickness in the inner ring region and central region.

关 键 词：黄斑色素密度 黄斑厚度 眼轴长度 近视 视网膜 

分 类 号：R774.5[医药卫生—眼科]