热休克蛋白47在胶质瘤中的研究进展  

Progress of heat shock protein 47 in glioma

作　　者：王壮壮 段虎斌[1] Wang Zhuangzhuang;Duan Hubin(Department of Neurosurgery,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院神经外科,太原030001

出　　处：《肿瘤研究与临床》2022年第11期873-876,共4页Cancer Research and Clinic

基　　金：国家自然科学基金青年基金(30600637);中国博士后科学基金(2019T120195)。

摘　　要：热休克蛋白47(HSP47)主要参与调节肿瘤微环境(TME)中胶原蛋白的折叠、分泌和成熟,并在人类癌症中广泛扩增。HSP47已被证实在多种颅外肿瘤中过表达。在胶质瘤中,HSP47的表达量与胶质瘤的分级相关,参与胶质瘤的增殖、侵袭、血管形成、免疫调节,并对胶质瘤的TME进行调节,促进胶质瘤干细胞的存活,可能与胶质瘤的异质性有关。文章对HSP47在胶质瘤发生、发展中的研究进展进行综述,探讨HSP47对胶质瘤的增殖和侵袭、靶向治疗和免疫治疗的重要意义。Heat shock protein 47(HSP47)is mainly involved in regulating collagen folding,secretion and maturation in the tumor microenvironment(TME)and is widely amplified in human cancers.HSP47 has been shown to be overexpressed in a variety of extracranial tumors.In glioma,the expression of HSP47 correlates with the grading of glioma and is involved in proliferation,invasion,angiogenesis,and immune regulation of glioma,regulates the TME of glioma,and promotes the survival of glioma stem cells,which may be related to the heterogeneity of glioma.This article reviews the progress of HSP47 in the development and progression of glioma,and discusses the significances of HSP47 in the proliferation,invasion,targeted therapy and immunotherapy of glioma.

关 键 词：热休克蛋白47 胶质瘤 血管形成 免疫疗法 分子靶向治疗 

分 类 号：R739.41[医药卫生—肿瘤]