肺癌患者化疗期间症状群的动态研究  

作　　者：傅郭妹芝 苏文敏[1] 章立楠[1] 周成伟[1] 赵伟军[1] 

机构地区：[1]宁波大学医学院附属医院,315000

出　　处：《浙江临床医学》2022年第11期1658-1661,共4页Zhejiang Clinical Medical Journal

基　　金：宁波市科技计划项目(202002N3179)。

摘　　要：目的观察肺癌患者化疗期间症状群的动态变化。方法采用方便抽样的方法选取晚期肺癌患者144例。采用中文版MD安德森症状量表(MD Anderson Symptom Inventory,MDASI)和修订版MDASI肺癌模块分别在化疗前(T1)、化疗第1个周期后的1周内(T2),化疗4个周期后(T3)三个不同时间点评估患者的症状。通过主成分分析确定症状群。结果在3个时间点发现了6个症状群。有3个症状群(心理症状群、感知症状群和肺癌特异性症状群)在各时间点上保持稳定。身体症状群在T1时出现,在T2和T3时消失;在T2和T3期新出现化疗症状群和胃肠道症状群。结论在肺癌患者化疗期间,症状群随着时间的推移表现出一定的稳定性和变异性。对肺癌患者的症状群轨迹的理解有助于有效评估、预防和管理多种并发症状,及时制定预防性干预措施,减少化疗患者的症状负担。Objective To investigate the dynamic changes of symptom clusters in patients with lung cancer during chemotherapy.Methods 144 patients with advanced lung cancer were selected by convenient sampling method.The Chinese MD Anderson Symptom Inventory(MDASI)and the revised MDASI lung cancer module were used to assess the patients'symptoms at three different time points:before chemotherapy(T1),within 1 week after the first cycle of chemotherapy(T2),and after 4 cycles of chemotherapy(T3).Symptom clusters were determined by exploratory factor analysis.Results Six symptom clusters were found at three time points.Three symptom clusters(psychological,perceived,and lung cancer-specific)remained stable at each time point.The physical symptom cluster appeared at T1 and disappeared at T2 and T3.The chemotherapy symptom cluster and the gastrointestinal symptom cluster newly appeared at T2 and T3.Conclusion During chemotherapy in lung cancer patients,the symptom cluster shows some stability and variability over time.The understanding of symptom cluster trajectories in lung cancer patients can help to effectively assess,prevent and manage multiple complication symptoms,timely develop preventive interventions,and reduce the symptom burden in chemotherapy patients.

关 键 词：肺癌 化疗 症状群 主成分分析 

分 类 号：R734.2[医药卫生—肿瘤]