青年乳腺癌患者临床病理特征及生存影响因素分析  

Analysis of clinicopathological features and factors influencing the survival of young breast cancer patients

作　　者：田保国[1] 王伟刚[1] 徐晓琴[1] 王艳[1] 杜丽莉[1] 张晓芳 孙婷[1] 史艳春[1] 荆结线[1] Tian Baoguo;Wang Weigang;Xu Xiaoqin;Wang Yan;Du Lili;Zhang Xiaofang;Sun Ting;Shi Yanchun;Jing Jiexian(Department of Etiology,Shanxi Province Cancer Hospital,Shanxi Hospital Affiliated to Cancer Hospital,Chinese Academy of Medical Sciences,Cancer Hospital Affiliated to Shanxi Medical University,Taiyuan 030013,China)

机构地区：[1]山西省肿瘤医院,中国医学科学院肿瘤医院山西医院,山西医科大学附属肿瘤医院病因室,太原030013

出　　处：《肿瘤研究与临床》2022年第10期755-758,共4页Cancer Research and Clinic

基　　金：山西省自然科学基金(201701D121167)。

摘　　要：目的探讨青年乳腺癌患者(诊断年龄<35岁)临床病理特征及生存影响因素,为青年乳腺癌的防治提供依据。方法回顾性分析2015年1月至2016年12月山西省肿瘤医院初次诊断的女性青年乳腺癌患者的流行病学和临床病理学资料,包括诊断年龄、生育史、流产史、绝经状态及免疫组织化学结果等。采用Cox比例风险模型进行单因素和多因素分析。结果共收集118例青年乳腺癌患者,中位诊断年龄为31岁。118例中,113例(95.8%)为浸润性癌,65例(55.1%)肿瘤长径≤20 mm,61例(51.7%)为N0期,112例(94.9%)为M0期。雌激素受体、孕激素受体、人表皮生长因子受体2阳性率分别为73.7%(87/118)、69.5%(82/118)、28.8%(34/118)。分子分型方面,Luminal B型患者比例最高(55.1%,65/118)。中位随访时间60个月,患者总生存率为78.8%。多因素分析结果显示,TNM分期是青年乳腺癌患者总生存的独立影响因素(HR=7.858,95%CI 2.924~21.120,P<0.001)。结论青年乳腺癌患者具有独特的临床病理特征,TNM分期是影响其预后的独立危险因素。个体化治疗有助于提高患者生命质量,延长生存时间。Objective To explore the clinicopathological characteristics and factors influencing the survival of young breast cancer patients with diagnostic age below 35 years,and to provide the basis for the prevention and treatment of young breast cancer patients.Methods Epidemiological and clinicopathological data of young female patients with newly diagnosed breast cancer from Shanxi Province Cancer Hospital between January 2015 and December 2016 were retrospectively analyzed.The data included age at diagnosis,reproductive history,history of abortion,menopausal status,and immunohistochemical results.Univariate and multivariate analysis were performed by using Cox regression model.Results A total of 118 young breast cancer patients were collected,and the median age was 31 years old.Among them,the vast majority of 118 young breast cancer patients were invasive cancer(113 cases,accounting for 95.8%);there were 65 cases(55.1%)with tumor diameter≤20 mm,61 cases(51.7%)at N0 stage,and 112 cases(94.9%)at M0 stage.The positive rates of estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor-2(HER2)were 73.7%(87/118),69.5%(82/118)and 28.8%(34/118),respectively.Luminal B breast cancer was the predominant molecular subtype,accounting for 55.1%(65/118).By the end of follow-up(median follow-up period of 60 months),the overall survival rate of young breast cancer patients was 78.8%.Multivariate analysis showed that TNM staging was an independent factor affecting overall survival in young breast cancer patients(HR=7.858,95%CI 2.924-21.120,P<0.001).Conclusions Young breast cancer patients have unique clinicopathological features and TNM staging is an independent factor affecting the prognosis.Individualized treatment helps to improve the quality of life and prolong the survival time of patients.

关 键 词：乳腺肿瘤 青年女性 临床病理特征 预后因素 

分 类 号：R737.9[医药卫生—肿瘤]