Oxygen and Glucose Transportation and Distribution on 3D Osteochondral Scaffold in Silico Model  

作　　者：Ziyu Liu Hao Huang Jingying Yang Maryam Tamaddon Haoyu Wang Yingying Gu Zhenyun Shi Chaozong Liu 

机构地区：[1]Division of Surgery and Interventional Science,Royal National Orthopaedic Hospital,University College London,Stanmore,London HA74LP,UK [2]Beijing Advanced Innovation Centre for Biomedical Engineering,School of Engineering Medicine,Beihang University,Beijing 100083,China [3]School of Mechanical Engineering and Automation,Beihang University,Beijing 100191,China

出　　处：《Journal of Bionic Engineering》2022年第4期1100-1108,共9页仿生工程学报（英文版）

基　　金：supported by Versus Arthritis UK(Grant no:21977);European Commission via a H2020-MSCA-RISE programme(BAMOS,Grant no:734156);Innovative UK via Newton Fund(Grant no:102872);Engineering and Physical Science Research Council(EPSRC)via DTP CASE programme(Grant no:EP/T517793/1).

摘　　要：Nutrients supply especially like nutrients and oxygen play vital role in tissue engineering process.It is found that tissue could not grow very well in the middle of the scaffold because few nutrients could transport to the middle.Nutrient limitations would reduce cell proliferation and differentiation.In that case,there is urgent need to understand the nutrient distribution for both in vitro and in vivo study,as no technology is able for researchers to observe the nutrients transport during those process.In this paper,a numerical model coupling with VOF(volume of fluid)model and species transport model together for predicting the distribution of oxygen and glucose in the scaffold after implantation in to the site is developed.Comparing with our previous in vivo tests,the regenerated tissue distribution has a similar trend as oxygen distribution rather than glucose.The reported scaffold manufactured by additive manufacturing provided a good interconnected structure which facilitated the nutrient transportation in the scaffold.Considering nutrient transportation,this numerical model could be used in better understanding the nutrients transportation in the scaffold,and leading to a better understanding of tissue formation in the scaffold.

关 键 词：Nutrient transport SCAFFOLD Nutrient distribution Computational fluid dynamic Discrete phase model 

分 类 号：P73[天文地球—海洋科学]