Beware the intruder:gasodermin A as molecular guardian preventing systemic dissemination of group A streptococci following local skin infection  

作　　者：Mahyar Aghapour Surender Surender Dunja Bruder 

机构地区：[1]Infection Immunology Group,Institute of Medical Microbiology,Infection Control and Prevention,Health Campus Immunology,Infectiology and Inflammation,Otto-von-Guericke University,Magdeburg,Germany [2]Immune Regulation Group,Helmholtz Centre for Infection Research,Braunschweig,Germany

出　　处：《Cellular & Molecular Immunology》2022年第7期761-763,共3页中国免疫学杂志（英文版）

摘　　要：Pyroptosis represents a host-protective mechanism that promotes clearance of pathogens by initiating the recruitment of immune cells to the site of infection.In a study recently published in Nature,Deng et al.extensively outlined a hitherto unknown role of the group A Streptococcus(GAS)-derived cysteine protease streptococcal pyrogenic exotoxin B(SpeB)in gasodermin A(GSDMA)cleavage as the primary step in induction of pyroptosis.As clearly shown in GSDMA-deficient mice infected with SpeBproducing GAS,this cleavage event is key to preventing the systemic spread and fatal course of GAS following local skin infection[1].

关 键 词：protective INFECTION LOCAL 

分 类 号：R36[医药卫生—病理学]