Aging induces severe SIV infection accompanied by an increase in follicular CD8+T cells with overactive STAT3 signaling  

作　　者：Hong-Yi Zheng Xue-Hui Wang Xiao-Yan He Min Chen Ming-Xu Zhang Xiao-Dong Lian Jia-Hao Song Yan Hu Wei Pang Yun Wang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng 

机构地区：[1]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences,KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases,Center for Biosafety Mega-Science,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan,650223,China [2]School of Life Sciences,University of Science and Technology of China,Hefei,Anhui,230026,China [3]Kunming College of Life Science,University of Chinese Academy of Sciences,Kunming,Yunnan,650204,China [4]National Resource Center for Non-Human Primates,National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility),Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan,650107,China

出　　处：《Cellular & Molecular Immunology》2022年第9期1042-1053,共12页中国免疫学杂志（英文版）

基　　金：The work was supported by the National Key R&D Program of China(2021YFC2301703);National Natural Science Foundation of China(81771770,81671627,U1802284,81971548,82071847);National Resource Center for Non-Human Primates.

摘　　要：The number of elderly people living with HIV is increasing globally,and the condition of this population is relatively complicated due to the dual effects of aging and HIV infection.However,the impact of HIV infection combined with aging on the immune homeostasis of secondary lymphoid organs remains unclear.Here,we used the simian immunodeficiency virus mac239(SIVmac239)strain to infect six young and six old Chinese rhesus macaques(ChRMs)and compared the infection characteristics of the two groups in the chronic stage through multiplex immunofluorescence staining of lymph nodes.The results showed that the SIV production and CD4/CD8 ratio inversion in old ChRMs were more severe than those in young ChRMs in both the peripheral blood and the lymph nodes,especially when a large number of CD8+T cells infiltrated the follicles and germinal centers.STAT3 in these follicular CXCR5+CD8+T cells was highly activated,with high expression of granzyme B,which might be caused by the severe inflammatory milieu in the follicles of old ChRMs.This study indicates that aging may be a cofactor involved in SIV-induced immune disorders in secondary lymphoid tissues,affecting the effective antiviral activity of highly enriched follicular CXCR5+CD8+cells.

关 键 词：SIV AGING Follicle CD8 T cells 

分 类 号：R51[医药卫生—内科学]