肠易激综合征的内脏高敏感化机制及其相应的靶点研究  

Research of visceral hypersensitization mechanism and corresponding target in irritable bowel syndrome

作　　者：戴亨纷 陈爱琴[2,3] 林春 DAI Hengfen;CHEN Aiqin;LIN Chun(Department of Pharmacy,Affiliated Fuzhou First Hospital of Fujian Medical University,Fuzhou 350009;Pain Research Institute of Fujian Medical University;Key Laboratory of Brain Aging and Neurodegenerative Diseases,School of Basic Medical Sciences,Fujian Medical University,China)

机构地区：[1]福建医科大学附属福州市第一医院药学部,福建福州350009 [2]福建医科大学疼痛研究所 [3]福建医科大学基础医学院脑老化与神经变性疾病重点实验室

出　　处：《胃肠病学和肝病学杂志》2022年第11期1219-1224,共6页Chinese Journal of Gastroenterology and Hepatology

基　　金：福建省自然科学基金项目(2021J011304)。

摘　　要：明确肠易激综合征(irritable bowel syndrome,IBS)的病因和发病机制一直是基础研究的热点,目前研究主要认为与内脏高敏感化、胃肠道动力、黏膜免疫、肠道炎症、肠道微生态、脑-肠轴及脑肠肽异常,以及饮食、精神心理等因素有关。IBS主要的病理生理学基础是内脏高敏感化,其形成机制包括内脏感觉传入神经异常、脊髓神经元兴奋性增加、中枢神经系统感知功能的适应性改变。神经递质、细胞因子和其他递质如肽和神经肽等被认为介导从外周到中枢途径的内脏感受信号传导,所以内脏高敏感化可以发生在IBS患者肠道感受器、脊髓、脑、脑-肠轴信号传导途中等。To clarify the etiology and pathogenesis of irritable bowel syndrome(IBS)has always been a hotspot of basic research.Current studies mainly believe that IBS is related to visceral hypersensitivity,gastrointestinal motility,mucosal immunity,intestinal inflammation,intestinal microecology,abnormal brain-gut axis and brain-gut peptide,diet,mental and psychological factors.The main pathophysiological basis of IBS is visceral hypersensitivity,and its formation mechanism includes abnormal visceral sensory afferent nerve,increased excitability of spinal cord neurons,and adaptive changes of sensory function of central nervous system.Neurotransmitters,cytokines and other transmitters such as peptides and neuropeptides were thought to mediate visceral sensory signal transduction from the peripheral to the central pathway,so visceral hypersensitivity might occur in the intestinal receptors,spinal cord,brain and brain-gut axis signal transduction in patients with IBS.

关 键 词：肠易激综合征 内脏高敏感化 中枢机制 外周机制 药物靶点 

分 类 号：R574[医药卫生—消化系统]