新型甜味剂纽甜结晶工艺优化研究  

Study on Optimization of New Sweetener Neotame in Process of Solution Crystallization

作　　者：苑芯月 于小颖 李跃东 李恩霞 程燕 杨斐斐 薛富民 孙齐磊[2] Yuan Xinyue;Yu Xiaoying;Li Yuedong;Li Enxia;Cheng Yan;Yang Feifei;Xue Fumin;Sun Qilei(School of Pharmaceutical Sciences,Shandong Analysis and Test Center,Qilu University of Technology(Shandong Academy of Science),Jinan 250014,China;School of Materials Science and Engineering,Shandong Jianzhu University,Jinan 250101,China;Jinan Chenghui Shuangda Chemical Co.,Ltd.,Jinan 250101,China;Shandong Chenghui Shuangda Pharmaceutical Co.,Ltd.,Dezhou 253000,China)

机构地区：[1]齐鲁工业大学(山东省科学院)山东省分析测试中心药学院,山东济南250014 [2]山东建筑大学材料科学与工程学院,山东济南250101 [3]济南诚汇双达化工有限公司,山东济南250101 [4]山东诚汇双达药业有限公司,山东德州253000

出　　处：《山东化工》2022年第23期11-14,18,共5页Shandong Chemical Industry

基　　金：山东省重大创新工程(2022CXGC010506,2020CXGC010506,2021CXGC010514,2021CXGC010811);2021年度山东省重点扶持区域引进急需紧缺人才项目。

摘　　要：通过过程分析和优化,制备了纯A晶型的纽甜长棒状晶体。与细针形晶体比较,长棒晶体在堆密度、水分、收率以及粒度分布等方面占有优势。考察了过饱和度、晶种量、搅拌速率、溶剂配比等对纽甜晶习的影响,确定了纽甜结晶工艺关键影响参数。Based on process analysis and optimization of neotame crystallization in solutions,neotame of form A was acquired with long rod shape.Compared with the needle products,the long rod crystal has advantages in bulk density,moisture,yield and particle size distribution.The effects of supersaturation,seed quantity,stirring rate and solvent ratio on the crystal habit of neotame were investigated,and the key influencing parameters of neotame crystallization process were determined.

关 键 词：纽甜 粒度分布 松堆密度 工艺优化 

分 类 号：TQ460[化学工程—制药化工]