依达拉奉联合静脉溶栓对急性脑梗死合并糖尿病患者血流动力学及颈动脉超声指标的影响  

Effects of Edaravone Combined with Intravenous Thrombolysis on Hemodynamics and Carotid Ultrasound in Patients with Acute Cerebral Infarction Complicated with Diabetes

作　　者：刘就娣 倪晓俊[1] 林嘉隆 吴小燕[1] LIU Jiu-Di;NI Xiao-Jun;LIN Jia-Long;WU Xiao-Yan(Department of Neurology,The Fourth Affiliated Hospital of Guangzhou Medical University(Zengcheng District People's Hospital),Guangzhou 511300,China;Health Management Center,The Fourth Affiliated Hospital of Guangzhou Medical University(Zengcheng District People's Hospital),Guangzhou 511300,China)

机构地区：[1]广州医科大学附属第四医院(增城区人民医院)神经内二科,广州511300 [2]广州医科大学附属第四医院(增城区人民医院)健康管理中心,广州511300

出　　处：《中国药物经济学》2022年第11期62-64,68,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨依达拉奉联合静脉溶栓对急性脑梗死(ACI)合并糖尿病患者血流动力学及颈动脉超声指标的影响。方法选取2020年4月至2022年3月于广州医科大学附属第四医院治疗的88例ACI合并糖尿病患者作为研究对象,按随机数字表法分为观察组与对照组,各44例。对照组采用静脉溶栓治疗,于对照组基础上,观察组采用依达拉奉治疗。比较两组血流动力学、颈动脉超声指标。结果治疗后两组脑动脉平均血流速度(Vm)、舒张期血流速度(Vd)、收缩期峰值血流速度(Vs)高于治疗前,且观察组Vm为(136.06±27.55)cm/s、Vd为(120.67±19.50)cm/s、Vs为(156.68±31.45)cm/s,高于对照组的(119.82±23.34)cm/s、(108.71±16.49)cm/s、(138.54±27.71)cm/s,差异有统计学意义(P<0.05);治疗后两组颈总动脉舒张期内径(Dd)、收缩期内径(Ds)及内-中膜厚度(IMT)低于治疗前,且观察组Dd为(6.70±0.34)mm、Ds为(7.42±0.42)mm、IMT为(728.99±37.62)μm,低于对照组的(6.91±0.38)mm、(7.74±0.49)mm、(761.41±45.58)μm,差异有统计学意义(P<0.05)。结论ACI合并糖尿病患者采用依达拉奉与静脉溶栓联合治疗有利于控制病情进展,改善患者的颈动脉超声指标及脑血流动力学,是治疗ACI合并糖尿病的一种有效方法。Objective To explore the effects of edaravone combined with intravenous thrombolytic therapy on hemodynamics and carotid ultrasound indexes in patients with acute cerebral infarction(ACI)complicated with diabetes.Methods A total of 88 patients with ACI complicated with diabetes treated in the Fourth Affiliated Hospital of Guangzhou Medical University from April 2020 to March 2022 were selected and divided into two groups according to random number table method,with 44 patients in each group.The control group was treated with intravenous thrombolytic therapy,and the observation group was treated with edaravone based on the control group.Hemodynamics and carotid ultrasound indexes were compared between the two groups.Results After treatment,the mean blood flow velocity(Vm),diastolic blood flow velocity(Vd)and peak systolic blood flow velocity(Vs)in both groups were higher than before treatment.In the observation group,Vm was(136.06±27.55)cm/s,Vd was(120.67±19.50)cm/s,Vs was(156.68±31.45)cm/s.Compared with control group(119.82±23.34)cm/s,(108.71±16.49)cm/s,(138.54±27.71)cm/s,the differences were statistically significant(P<0.05).After treatment,the diastolic inner diameter(Dd),systolic inner diameter(Ds)and intimedia thickness(IMT)of common carotid artery in the two groups were lower than before,and Dd,Ds and IMT in the observation group were(6.70±0.34)mm,(7.42±0.42)mm and(728.99±37.62)μm,respectively.Compared with control group(6.91±0.38)mm,(7.74±0.49)mm,(761.41±45.58)μm,the difference was statistically significant(P<0.05).Conclusion The combined treatment of edaravone and intravenous thrombolytic therapy in ACI patients with diabetes is beneficial to control the progression of the disease,improve the carotid ultrasound indicators and cerebral hemodynamics,and is an effective method for the treatment of ACI patients with diabetes.

关 键 词：急性脑梗死 糖尿病 依达拉奉 静脉溶栓 血流动力学 颈动脉超声指标 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R587.2[医药卫生—临床医学] R971