金圣草黄素的合成工艺研究  

Research on the Synthesis Process of Chryseriol

作　　者：刘世君[1] 褚朝森[1,2] 王晓丽 顾明华[1] 李天雪[1,2] LI Shi-jun;CHU Chao-sen;WANGXiao-li;GU Ming-hua;LI Tian-xue(Lianyungang TCM Branch of Jiangsu Union Technical Institute,Lianyungang Jiangsu 222007,China;Lianyungang Common Technological Center for Drug Research and Development,Lianyungang Jiangsu 222007,China)

机构地区：[1]江苏联合职业技术学院连云港中医药分院,江苏连云港222007 [2]连云港市药物研发共性技术中心,江苏连云港222007

出　　处：《当代化工》2022年第11期2610-2613,共4页Contemporary Chemical Industry

基　　金：连云港市“521”人才基金项目(项目编号:2020-2023)。

摘　　要：以2-氯-1-(2,4,6-三羟基苯基)乙酮为原料,在超声波和相转移催化剂TBAB辅助下与香兰素发生环合反应制备金圣草黄素。研究了TBAB用量、超声频率、超声功率、温度及时间对反应结果的影响,确定了最佳反应条件为TBAB 15%(摩尔分数)、50k Hz、350W、80℃、5 h,反应收率94.3%,产物纯度99.1%。Using 2-chloro-1-(2,4,6-trihydroxyphenyl)-ethanone as starting material, chryseriol was synthesized by cyclization reaction with vanillin under ultrasound and TBAB condition. The effect of TBAB dosage, ultrasonic frequency, ultrasonic power, temperature and time on the reaction results was studied. The result showed that the optimum reaction condition was as follows: TBAB 15%(mole fraction), 50 kHz, 350 W, 80 ℃, reaction time 5 h.Under above conditions, the yield of the cyclization reaction was 94.3%,the purity of product was 99.1%.

关 键 词：金圣草黄素 超声波 TBAB 

分 类 号：TQ031.5[化学工程]