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作 者:Binliang Tang Kailin Li Yuan Cheng Guimin Zhang Pengying An Yutian Sun Yue Fang Hui Liu Yang Shen Yifan Zhang Ye Shan E´tienne de Villers-Sidani Xiaoming Zhou
机构地区:[1]Key Laboratory of Brain Functional Genomics of Ministry of Education,Shanghai Key Laboratory of Brain Functional Genomics,School of Life Sciences,East China Normal University,Shanghai 200062,China [2]New York University-East China Normal University Institute of Brain and Cognitive Science,NYU-Shanghai,Shanghai 200062,China [3]Department of Neurology and Neurosurgery,Montreal Neurological Institute,McGill University,Montreal,QC H3A 2B4,Canada
出 处:《Neuroscience Bulletin》2022年第11期1292-1302,共11页神经科学通报(英文版)
基 金:the National NaturalScienceFoundationofChina(32171134and 32161160325);the National Science and Technology Innovation 2030 Major Program(2022ZD0204804);a Project of Shanghai Science and Technology Commission(21490713200);the Program of Introducing Talents of Discipline to Universities(B16018);a matching fund from the NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai.
摘 要:Developmental exposure to bisphenol A(BPA),an endocrine-disrupting contaminant,impairs cognitive function in both animals and humans.However,whether BPA affects the development of primary sensory systems,which are the first to mature in the cortex,remains largely unclear.Using the rat as a model,we aimed to record the physiological and structural changes in the primary auditory cortex(A1)following lactational BPA exposure and their possible effects on behavioral outcomes.We found that BPA-exposed rats showed significant behavioral impairments when performing a sound temporal rate discrimination test.A significant alteration in spectral and temporal processing was also recorded in their A1,manifested as degraded frequency selectivity and diminished stimulus rate-following by neurons.These post-exposure effects were accompanied by changes in the density and maturity of dendritic spines in A1.Our findings demonstrated developmental impacts of BPA on auditory cortical processing and auditory-related discrimination,particularly in the temporal domain.Thus,the health implications for humans associated with early exposure to endocrine disruptors such as BPA merit more careful examination.
关 键 词:Auditory cortex Auditory behavior BPA exposure Cortical processing PLASTICITY
分 类 号:R338[医药卫生—人体生理学]
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