周围型肺癌CT征象与Ki-67、p53表达的关系  

Relationship between CT signs and Ki-67,p53 in peripheral lung cancer

作　　者：吴志涛 上官伦 徐冰洁 WU Zhitao;SHANGGUAN Lun;XU Bingjie(Department of Imaging,Nanping Second Hospital,Nanping 354200,China)

机构地区：[1]南平市第二医院影像科,福建南平354200

出　　处：《分子影像学杂志》2023年第1期124-128,共5页Journal of Molecular Imaging

基　　金：南平市科技计划项目(N2021J044)。

摘　　要：目的探讨周围型肺癌(PLC)CT征象与Ki-67、p53表达的关系。方法选取2016年1月~2022年2月在本院就诊的108例PLC患者为研究对象,采用飞利浦256层螺旋CT检查患者的CT征象,并检测PLC组织中Ki-67、p53的表达水平,分析PLC患者的病理组织类型、分化程度以及CT征象与Ki-67和p53表达的关系。结果PLC组织中,Ki-67和p53阳性表达率分别为69.44%(75/108)、51.85%(56/108);CT主要表现为瘤体直径≥3.0 cm、分叶征、棘状突起征、毛刺征、磨玻璃征、增强值≥20 Hu和肺门、纵隔淋巴结肿大,而胸膜凹陷征、空气支气管征、空洞征、空泡征、钙化征相对较少;腺癌的Ki-67阳性表达率低于鳞癌(P<0.05),腺癌和鳞癌的p53阳性表达率差异无统计学意义(P>0.05);PLC的分化程度越低,Ki-67和p53阳性表达率越高(P<0.05);瘤体直径≥3.0 cm、有分叶征、棘状突起征、毛刺征、增强值≥20 Hu和肺门、纵隔淋巴结肿大的PLC,Ki-67阳性表达率较高,且有磨玻璃征和空泡征的PLC,Ki-67阳性表达率较低(P<0.05);瘤体直径≥3.0 cm、有毛刺征、棘状突起征、分叶征、增强值≥20 Hu和肺门、纵隔淋巴结肿大的PLC,p53阳性表达率较高(P<0.05)。结论PLC患者Ki-67、p53的表达与CT征象密切相关。Objective To explore the relationship between CT signs and Ki-67,p53 in peripheral lung cancer(PLC).Methods A total of 108 patients with PLC treated in the hospital were enrolled between January 2016 and February 2022.CT signs were examined by Philips 256-slice spiral CT.The expression levels of Ki-67 and p53 in PLC tissues were detected.The relationship between pathological tissue types,differentiation degree,CT signs and Ki-67,p53 was analyzed.Results In PLC tissues,positive expression rates of Ki-67 and p53 were 69.44%(75/108)and 51.85%(56/108),respectively.The main CT findings included pleural indentation,tumor diameter≥3.0 cm,lobulation sign,spiculate protuberance sign,spicule sign,enhancement value≥20 Hu,hilar and mediastinal lymph node enlargement,while CT findings(air bronchus sign,cavity sign,glass sign,vacuole sign,calcification sign)were relatively rare.The positive expression rate of Ki-67 in adenocarcinoma was lower than that in squamous cell carcinoma(P<0.05),but there was no significant difference in the positive expression rate of p53 between adenocarcinoma and squamous cell carcinoma(P>0.05).The lower the differentiation degree of PLC,the higher the positive expression rates of Ki-67 and p53(P<0.05).The positive expression rate of Ki-67 was higher in patients with tumor diameter≥3.0 cm,lobulation sign,spiculate protuberance sign,spicule sign,enhancement value≥20 Hu,hilar and mediastinal lymph node enlargement,while which was lower in patients with glass sign and vacuole sign(P<0.05).The positive expression rate of p53 was higher in patients with tumor diameter≥3.0 cm,lobulation sign,spiculate protuberance sign,spicule sign,enhancement value≥20 Hu,hilar and mediastinal lymph node enlargement(P<0.05).Conclusion The expressions of Ki-67 and p53 are closely related to CT signs in PLC patients.

关 键 词：周围型肺癌 CT征象 KI-67 P53 

分 类 号：R734.2[医药卫生—肿瘤]