北京昌平地区HBsAg阳性孕妇HBV血清标志物与HBV-DNA载量分析  

The Analysis of the Patterns of HBV Markers in Serum and the HBV-DNA Load in HBsAg+Pregnant Women in Changping of Beijing

作　　者：邱爽[1] 孔卓[1] 徐东江[1] 宗春杰 王薇 金国红[1] QIU Shuang;KONG Zhuo;XU Dong-jiang(Department of Clinical Laboratory,Beijing Jishuitan Hospital,Beijing100035,China)

机构地区：[1]北京积水潭医院检验科,北京100035

出　　处：《中国实验诊断学》2022年第11期1602-1605,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨北京昌平地区孕妇HBV血清标志物与HBV-DNA载量之间的关系,为监控孕期乙肝病毒感染和预防HBV母婴传播提供参考。方法以2017~2021在北京积水潭医院建档孕妇为研究对象,检测HBV血清标志物五项和HBV-DNA载量,并对结果进行统计分析。结果15691例孕妇中HBsAg阳性率为2.09%,5年间HBsAg阳性率逐年降低(P<0.05),HBsAg阳性率随年龄组别升高而增加(P<0.05)。328例HBsAg阳性孕妇HBV标志物(HBVM)模式有7种,其中模式Ⅰ(HBsAg^(+)、HBeAg^(+)、HBcAb^(+),大三阳)和Ⅱ(HBsAg^(+)、HBeAb^(+)、HBcAb^(+),小三阳)共有300例,占7种组合模式的91.46%。328例HBsAg阳性孕妇中,87例HBV-DNA>500copies/ml,其中模式Ⅰ、Ⅱ共79例;7种HBVM模式中HBeAg阳性的孕妇HBV-DNA阳性率(72.97%)高于HBeAg阴性孕妇(20.27%)(P<0.01);HBeAg^(+)组患者的平均病毒载量高于HBeAg-组(P<0.01)。结论HBVM与HBV-DNA阳性率及高病毒载量密切相关,产前筛查对孕产妇及新生儿的乙肝预防及干预具有重要意义;孕妇HBVM检测结果中HBsAg^(+)HBeAg^(+)者HBV-DNA载量较高,是防控母婴垂直传播的重点。Objective This study showed the relationship between the patterns of HBV markers(HBVM)in serum of the pregnant women and the viral load(VL)of HBV-DNA in Changping,Beijing,which would provide a reference for preventing mother-to-child transmission of HBV during pregnancy.Methods Five serum markers of HBV and the HBV-DNA load in pregnant women of Beijing Ji Shuitan Hospital from 2017to 2021were detected,and the results were statistically analyzed.Results In 15691pregnant women,the positive rate of HBsAg that was 2.09%,and decreased by years from 2017to 2021,but increased significantly with age(P<0.05).Among the 328HBsAg^(+)pregnant women,there were 7patterns of HBV markers(HBVM)combination,of which 300cases(91.46%)were PatternⅠ(HbsAg^(+)HbeAg^(+)HbcAb^(+))andⅡ(HbsAg^(+)HbeAb^(+)HbcAb^(+)).There were 87cases of HBV-DNA>500copies/ml in the HBsAg^(+)pregnant women,and 79of the 87patients were PatternⅠandⅡ.The positive rate in HBV-DNA was72.97%in the HBeAg^(+)pregnant women and was higher than that in the HBeAg-patients(20.27%)(P<0.01).Moreover,the viral load of HBV in HBeAg^(+)patients was significantly higher than in the HBeAg patients(P<0.01).Conclusion The patterns of HBVM are closely related to the positive rate of HBV-DNA and high VL in serum of patients.Perinatal screening in HBVMs is of great significance for the infection of HBV from the pregnant women to their babies.The HBsAg^(+)HBeAg^(+)pregnant women are the focus of the mother-to-child infection blocking in HBV because of their high VL.

关 键 词：孕妇 乙型肝炎病毒血清标志物 HBV-DNA 病毒载量 

分 类 号：R575.1[医药卫生—消化系统]