Coassembly of Macrocyclic Amphiphiles for Anti-β-Amyloid Therapy of Alzheimer’s Disease  

作　　者：Yu-Chen Pan Hui Wang Xinxin Xu Han-Wen Tian Hong Zhao Xin-Yue Hu Yu Zhao Yang Liu Guihua Ding Qingbin Meng Bart Jan Ravoo Tao Zhang Dong-Sheng Guo 

机构地区：[1]College of Chemistry,Key Laboratory of Functional Polymer Materials,Ministry of Education,State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071 [2]College of Life Sciences,Key Laboratory of Bioactive Materials,Ministry of Education,Nankai University,Tianjin 300071 [3]College of Chemistry,Key Laboratory of Functional Polymer Materials,(Ministry of Education,State Key Laboratory of Medicinal Chemical Biology),Nankai University,Tianjin 300071 [4]State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Institute of Pharmacology and Toxicology,Beijing 100850 [5]Organic Chemistry Institute and Center for Soft Nanoscience(SoN),Westfälische Wilhelms-Universität Münster,Münster 48149

出　　处：《CCS Chemistry》2021年第9期2485-2497,共13页中国化学会会刊（英文）

基　　金：from NSFC(grant nos.51873090,31961143004,31771148,and 31900733);111 Project(grant no.B08011);the Fundamental Research Funds for the Central Universities,and NCC Fund(grant no.NCC2020FH04).

摘　　要：Based on the amyloid hypothesis,anti-β-amyloid(Aβ)therapy has dominated clinical trials for the prevention and treatment of Alzheimer’s disease(AD)in recent years.A key element of this strategy is the interaction between therapeutic agents and Aβ.However,the design and development of artificial receptors that may render selective and strong recognition toward Aβremains a huge challenge because of the complexity and size of peptide guests and their flexible conformation.

关 键 词：macrocyclic amphiphile heteromultivalent recognition fibril disintegration cognitive improvement Alzheimer’s disease 

分 类 号：R749[医药卫生—神经病学与精神病学] R318[医药卫生—临床医学]