Coordination Polymers Integrating Metalloimmunology with Immune Modulation to Elicit Robust Cancer Chemoimmunotherapy  

作　　者：Longlong Tian Yujie Zhu Jun Xu Ming Shao Wenjun Zhu Zhisheng Xiao Qian Chen Zhuang Liu 

机构地区：[1]Institute of Molecular Medicine,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127 [2]Institute of Functional Nano and Soft Materials(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices,Soochow University,Suzhou,Jiangsu 215123

出　　处：《CCS Chemistry》2021年第10期2629-2642,共14页中国化学会会刊（英文）

基　　金：supported by the National Research Programs of China(no.2016YFA0201200);the National Natural Science Foundation of China(nos.51525203,51761145041,and 51572180);the China Postdoctoral Science Foundation(no.2020M671143);Collaborative Innovation Center of Suzhou Nano Science and Technology,a Jiangsu Natural Science Fund for Distinguished Young Scholars(no.BK20170063);and a Project Funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,and a Project Funded for Postgraduate Research&Practice Innovation Program of Jiangsu Province(no.2019 SJKY19_2282).

摘　　要：Nanoscale coordination polymers(NCPs)constructed by metal ions and organic ligands via metal–ligand bonds have attracted great attention for their biomedical application.Herein,a new type of NCP is constructed from Zn-ions and 4-phenylimidazole(PI),the latter of which is an inhibitor of indoleamine 2,3-dioxygenase(IDO)and acts as an organic bridging ligand via Zn–N coordination bonds.

关 键 词：na noscale coord ination polymers metal-lo immunology chemoimmuno the rapy 

分 类 号：R730.51[医药卫生—肿瘤]