Asymmetric Spirocyclization Enabled by Iridium and Brønsted Acid-Catalyzed Formal Reductive Cycloaddition  

作　　者：Nan-Fang Mo Le Yu Ying Zhang Ya-Hong Yao Xun Kou Zhi-Hui Ren Zheng-Hui Guan 

机构地区：[1]Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education,Department of Chemistry&Materials Science,Northwest University,Xi’an 710127

出　　处：《CCS Chemistry》2021年第7期1775-1786,共12页中国化学会会刊（英文）

基　　金：the National Natural Science Foundation of China(grant nos.21971204 and 21622203);the Innovation Capability Support Program of Shaanxi Province(grant no.2020TD-022).

摘　　要：A catalytic,enantioselective spirocyclization of formanilides or formylindolines and enamides has been developed herein.The reaction proceeds through a sequential iridium-catalyzed hydrosilylation of tertiary formanilides and a chiral phosphoric acid-catalyzed formal cycloaddition of exocyclic enamides,thus providing straightforward access to a diverse array of enantioenriched azaspirocycles under mild conditions.

关 键 词：asymmetric catalysis formanilides azaspirocycles chiral phosphoric acid ENAMIDES 

分 类 号：O64[理学—物理化学]