Extracellular Elastin Molecule Modulates Alzheimer’s AβDynamics In Vitro and In Vivo by Affecting Microglial Activities  

作　　者：Jingjing Li Yao Sun Yingxia Liang Jun Ma Bo Li Chao Ma Rudolph ETanzi Hongjie Zhang Kai Liu Can Zhang 

机构地区：[1]State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun [2]Genetics and Aging Research Unit,McCance Center for Brain Health,Mass General Institute for Neurodegenerative Disease,Department of Neurology,Massachusetts General Hospital and Harvard Medical School,Charlestown,MA [3]School of Engineering and Applied Sciences&Department of Physics,Harvard University,MA [4]Department of Chemistry,Tsinghua University,Beijing

出　　处：《CCS Chemistry》2021年第7期1830-1837,共8页中国化学会会刊（英文）

基　　金：from National Key R&D Program of China(grant no.2018YFA0902600);the Scientific Instrument Developing Project of the Chinese Academy of Sciences(grant no.ZDKYYQ20180001);the Jilin Province Science Fund for Excellent Young Scholars(20190103072JH),K.C.Wong Education Foundation(grant no.GJTD-2018-09);and the National Natural Science Foundation of China(grant nos.21704099,21877104,and 21834007)and the Cure Alzheimer’s Fund.

摘　　要：Alzheimer’s disease(AD)is a neurodegenerative disorder,and the etiology of AD has not been completely elucidated.It remains unknown how the components from the brain’s extracellular matrix(ECM),particularly fibrous entities,may influence the pathogenesis of AD.Herein,we report that treatment with elastin-like polypeptides(ELPs),a component of the brain ECM,significantly increases the extracellular levels of AD-related amyloid-beta(Aβ)peptides and decreases intracellular Aβlevels in human microglial cell model HMC3 cells(HMC3).

关 键 词：Alzheimer’s disease Aβpeptides elastin-like polypeptides microglia PHAGOCYTOSIS 

分 类 号：R74[医药卫生—神经病学与精神病学]