Host–Guest Interaction Driven Peptide Assembly into Photoresponsive Two-Dimensional Nanosheets with Switchable Antibacterial Activity  

作　　者：Xiaoming Xie Bo Gao Zhiyuan Ma Junqing Liu Jianfeng Zhang Jing Liang Zhijun Chen Lixin Wu Wen Li 

机构地区：[1]State Key Laboratory of Supramolecular Structure and Materials,College of Chemistry,Jilin University,Changchun 130012 [2]School of Life Sciences,Jilin Province Innovation Platform of Straw Comprehensive Utilization Technology,Jilin Agricultural University,Changchun 130118

出　　处：《CCS Chemistry》2021年第7期1949-1962,共14页中国化学会会刊（英文）

基　　金：supported by the National Natural Science Foundation of China(NSFC;21822201 and 21573091).

摘　　要：Selectively controlling the bioactivity of antimicrobial peptides is not only a fascinating scientific challenge but also a necessity in localized antibacterial therapy.Here,a smart antimicrobial system has been fabricated via host–guest driven dynamic selfassembly between a branched cyclodextrin and cationic linear peptides appended with azobenzene side chains.The self-assembly structure of the host–guest system could be controlled reversibly through the photoresponsive isomerization of azobenzene moieties.

关 键 词：PEPTIDE AZOBENZENE dynamic assembly PHOTORESPONSIVE antibacterial activity 

分 类 号：TB383[一般工业技术—材料科学与工程]